Successful treatment of Aspergillus fumigatus sternal osteomyelitis with isavuconazole in a heart transplant recipient

被引：12

作者：

Assaf, Ady ^{[1
]}

Faure, Emmanuel ^{[1
,2
]}

Sermet, Kevin ^{[1
]}

Loridant, Severine ^{[3
]}

Leroy, Jordan ^{[3
]}

Goeminne, Celine ^{[4
]}

Dozier, Aurelie ^{[1
]}

Chopin, Marie-Charlotte ^{[1
]}

Panaget, Sophie ^{[1
]}

Faure, Karine ^{[1
,2
]}

Vuotto, Fanny ^{[1
]}

机构：

[1] CHU Lille, Serv Malad Infect, F-59000 Lille, France

[2] Univ Lille, CIIL, Inst Pasteur Lille, CNRS,UMR9017,Inserm U1019,CHRU Lille, Lille, France

[3] Univ Lille, Lab Parasitol Mycol, Ctr Hosp Univ Lille, INSERM U995,LIRIC, Lille, France

[4] CHU Lille, Serv Cardiol, Hop Cardiol, Lille, France

来源：

TRANSPLANT INFECTIOUS DISEASE | 2020年 / 22卷 / 05期

关键词：

aspergillosis; heart transplantation; isavuconazole; sternal osteomyelitis; INVASIVE ASPERGILLOSIS; VORICONAZOLE; INFECTIONS; GUIDELINES; SOCIETY;

D O I：

10.1111/tid.13313

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 65-year-old man was diagnosed with an invasive Aspergillus fumigatus infection with sternal osteomyelitis 4 months after heart transplantation. Unfortunately, after 8 weeks patient developed severe cutaneous and neurological toxicities induced by voriconazole leading to drug discontinuation. Therefore, isavuconazole was chosen as second-line therapy. The patient presented a favorable outcome and tolerance was excellent after ten months monotherapy. Here, we report for a first time, an successful isavuconazole-based treatment of sternal osteomyelitis aspergillosis in a cardiac recipient.

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页数：4

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