International consensus guidance for management of myasthenia gravis: Executive summary

被引：728

作者：

Sanders, Donald B. ^{[1
]}

Wolfe, Gil I. ^{[2
]}

Benatar, Michael ^{[3
]}

Evoli, Amelia ^{[4
]}

Gilhus, Nils E. ^{[5
]}

Illa, Isabel ^{[6
,7
]}

Kuntz, Nancy ^{[8
,9
]}

Massey, Janice M. ^{[1
]}

Melms, Arthur ^{[10
,11
]}

Murai, Hiroyuki ^{[12
]}

Nicolle, Michael ^{[13
]}

Palace, Jacqueline ^{[14
]}

Richman, David P. ^{[15
]}

Verschuuren, Jan ^{[16
]}

Narayanaswami, Pushpa ^{[17
]}

机构：

[1] Duke Univ, Med Ctr, Dept Neurol, Durham, NC 27708 USA

[2] SUNY Buffalo, Sch Med & Biomed Sci, Dept Neurol, Buffalo, NY 14260 USA

[3] Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA

[4] Catholic Univ, Dept Neurol, Rome, Italy

[5] Univ Bergen, Dept Clin Med, N-5020 Bergen, Norway

[6] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Barcelona, Spain

[7] CIBERER U762, Barcelona, Spain

[8] Northwestern Feinberg Sch Med, Dept Pediat, Chicago, IL USA

[9] Northwestern Feinberg Sch Med, Dept Neurol, Chicago, IL USA

[10] Univ Klinikum Erlangen, Neurol Klin, Erlangen, Germany

[11] Univ Tubingen, Inst Clin Res, Tubingen, Germany

[12] Kyushu Univ, Grad Sch ofMed Sci, Dept Neurol Therapeut, Fukuoka, Japan

[13] Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada

[14] Oxford Univ Hosp Trust, John Radcliffe Hosp, Dept Clin Neurol, Oxford, England

[15] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA

[16] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands

[17] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA USA

来源：

NEUROLOGY | 2016年 / 87卷 / 04期

关键词：

GUIDELINES;

D O I：

10.1212/WNL.0000000000002790

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective:To develop formal consensus-based guidance for the management of myasthenia gravis (MG).Methods:In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened. The RAND/UCLA appropriateness methodology was used to develop consensus guidance statements. Definitions were developed for goals of treatment, minimal manifestations, remission, ocular MG, impending crisis, crisis, and refractory MG. An in-person panel meeting then determined 7 treatment topics to be addressed. Initial guidance statements were developed from literature summaries. Three rounds of anonymous e-mail votes were used to attain consensus on guidance statements modified on the basis of panel input.Results:Guidance statements were developed for symptomatic and immunosuppressive treatments, IV immunoglobulin and plasma exchange, management of impending and manifest myasthenic crisis, thymectomy, juvenile MG, MG associated with antibodies to muscle-specific tyrosine kinase, and MG in pregnancy.Conclusion:This is an international formal consensus of MG experts intended to be a guide for clinicians caring for patients with MG worldwide.

引用

页码：419 / 425

页数：7