Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma

被引:32
作者
Zanjani, Leili Saeednejad [1 ]
Madjd, Zahra [1 ,2 ]
Abolhasani, Maryam [1 ,3 ]
Rasti, Arezoo [1 ]
Fodstad, Oystein [4 ,5 ]
Andersson, Yvonne [4 ]
Asgari, Mojgan [1 ,3 ]
机构
[1] Iran Univ Med Sci, Oncopathol Res Ctr, Tehran, Iran
[2] Iran Univ Med Sci, Fac Adv Technol Med, Dept Mol Med, Tehran, Iran
[3] Iran Univ Med Sci, Hasheminejad Kidney Ctr, Tehran, Iran
[4] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Tumor Biol, N-0424 Oslo, Norway
[5] Univ Oslo, Fac Med, Inst Clin Med, N-0310 Oslo, Norway
关键词
cancer stem cells; CD44; renal cell carcinoma; tissue microarray; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; MICROSCOPIC VENOUS INVASION; INTERNATIONAL-SOCIETY; PROGNOSTIC VALUE; METASTASIS; MOLECULE; IDENTIFICATION; POPULATIONS; ACQUISITION;
D O I
10.2217/bmm-2017-0142
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Aim: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes. Discussion & conclusion: Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC.
引用
收藏
页码:45 / 61
页数:17
相关论文
共 56 条
[1]   Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[2]  
Botchkina Inna L., 2009, Cancer Genomics & Proteomics, V6, P19
[3]   Identification of a tumor-initiating stem cell population in human renal carcinomas [J].
Bussolati, Benedetta ;
Bruno, Stefania ;
Grange, Cristina ;
Ferrando, Ugo ;
Camussi, Giovanni .
FASEB JOURNAL, 2008, 22 (10) :3696-3705
[4]   Human renal cancer stem cells [J].
Bussolati, Benedetta ;
Dekel, Benjamin ;
Azzarone, Bruno ;
Camussi, Giovanni .
CANCER LETTERS, 2013, 338 (01) :141-146
[5]   Validation of tissue microarray technology in breast carcinoma [J].
Camp, RL ;
Charette, LA ;
Rimm, DL .
LABORATORY INVESTIGATION, 2000, 80 (12) :1943-1949
[6]   Molecular characterization of kidney cancer Association of Hyaluronic Acid Family With Histological Subtypes and Metastasis [J].
Chi, Andrew ;
Shirodkar, Samir P. ;
Escudero, Diogo O. ;
Ekwenna, Obi O. ;
Yates, Travis J. ;
Ayyathurai, Rajinikanth ;
Garcia-Roig, Michael ;
Gahan, Jeffrey C. ;
Manoharan, Murugesan ;
Bird, Vincent G. ;
Lokeshwar, Vinata B. .
CANCER, 2012, 118 (09) :2394-2402
[7]   The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy [J].
Clark, Peter E. .
KIDNEY INTERNATIONAL, 2009, 76 (09) :939-945
[8]   Renal-cell carcinoma [J].
Cohen, HT ;
McGovern, FJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2477-2490
[9]   Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance [J].
da Costa, Walter Henriques ;
Rocha, Rafael Malagoli ;
da Cunha, Isabela Werneck ;
Guimaraes, Gustavo Cardoso ;
Zequi, Stenio de Cassio .
INTERNATIONAL BRAZ J UROL, 2012, 38 (04) :456-465
[10]   Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells [J].
Debeb, Bisrat G. ;
Zhang, Xiaomei ;
Krishnamurthy, Savitri ;
Gao, Hui ;
Cohen, Evan ;
Li, Li ;
Rodriguez, Angel A. ;
Landis, Melissa D. ;
Lucci, Anthony ;
Ueno, Naoto T. ;
Robertson, Fredika ;
Xu, Wei ;
Lacerda, Lara ;
Buchholz, Thomas A. ;
Cristofanilli, Massimo ;
Reuben, James M. ;
Lewis, Michael T. ;
Woodward, Wendy A. .
MOLECULAR CANCER, 2010, 9