Visible-Light-Induced Metal-Free Decarboxylative Perfluoroalkylation of Aryl Acrylic Acids

被引：15

作者：

Yu, Mo ^{[1
]}

Niu, Kaikai ^{[1
]}

Wang, Ziwen ^{[1
,2
]}

Liu, Yuxiu ^{[1
]}

Wang, Qingmin ^{[1
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Res Inst Elementoorgan Chem,Frontiers Sci Ctr New, Tianjin 300071, Peoples R China

[2] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol y, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 41期

基金：

中国国家自然科学基金;

关键词：

ALPHA; BETA-UNSATURATED CARBOXYLIC-ACIDS; TRIFLUOROMETHYLATION; FLUORINE; ALKYNES; PHARMACEUTICALS; GENERATION; HALIDES;

D O I：

10.1021/acs.orglett.2c03088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Perfluoroalkylation is important for late-stage modification of biologically active molecules. Herein, we report a protocol for visible-light-induced perfluoroalkylation reactions of aryl acrylic acids. These reactions, which use perfluoroalkyl iodides as radical precursors and inexpensive eosin Y as a photocatalyst, proceed in a decarboxylative manner. The easy accessibility of perfluoroalkyl iodides and the broad substrate scope, mild conditions, and metal-free catalyst make this protocol applicable for the transformation of inexpensive raw materials to high-value chemicals.

引用

收藏

页码：7622 / 7626

页数：5

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