Gastroprotective Effect of Microencapsulated Myrtus communis Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions

被引：15
作者：
Mansour, Rim Ben [1 ]
Beji, Raja Serairi [1 ,2 ]
Wasli, Hanen [1 ]
Zekri, Sami [3 ]
Ksouri, Riadh [1 ]
Megdiche-Ksouri, Wided [1 ]
Cardoso, Susana M. [4 ,5 ]
机构：
[1] Ctr Biotechnol Borj Cedria, Lab Aromat & Med Plants, BP 901, Hammam Lif 2050, Tunisia
[2] High Sch Hlth Sci & Tech, BP 176,Bab Saadoun, Tunis 1007, Tunisia
[3] USCR, Unite Serv Communs Rech Microscopie Elect Transmi, Fac Med Tunis, Tunis 1029, Tunisia
[4] Univ Aveiro, LAQV REQUIMTE, P-3810193 Aveiro, Portugal
[5] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal
来源：
MOLECULES | 2022年 / 27卷 / 05期
关键词：
Myrtus communis; essential oil; microencapsulation; spray drying; gastroprotective activity; anti-inflammatory; OXIDATIVE STRESS; WALL MATERIALS; ALPHA-PINENE; ULCER; RATS; L; EXTRACT; PROSTAGLANDINS; PATHOGENESIS; POPULATIONS;
D O I：
10.3390/molecules27051566
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Myrtus communis L. essential oil (EO), mainly composed of myrtenyl acetate (30.6%), linalool (14.9%), alpha-pinene (11.10%) and 1,8-cineole or eucalyptol (9.9%), was microencapsulated with maltodextrin by emulsification and spray-drying, reaching a yield and efficiency of 43.7 and 48.7%, respectively. The microencapsulated myrtle EO (MMEO) was then evaluated regarding its gastroprotective activity in a model of ethanol/HCl-induced acute gastric ulcer in Wistar rats. Pretreatment with MMEO induced a remarkable inhibition of gastric lesions and acidity, correlated to high healing and protection percentages. Moreover, it exerted a potent anti-inflammatory effect on the gastric mucosa, counteracting EtOH-induced gastric lipoperoxidation and preventing the depletion of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Taken together, the gastroprotective action of encapsulated MMEO may be multi-factorial, and ascribable, at least in parts, to its anti-inflammatory and antioxidant properties.
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页数：13
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