Development of the alopecia areata scale for clinical use: Results of an academic-industry collaborative effort

被引：40

作者：

King, Brett A. ^{[1
]}

Mesinkovska, Natasha Atanaskova ^{[2
]}

Craiglow, Brittany ^{[1
]}

Kindred, Chesahna ^{[3
]}

Ko, Justin ^{[4
]}

McMichael, Amy ^{[5
]}

Shapiro, Jerry ^{[6
]}

Goh, Carolyn ^{[7
]}

Mirmirani, Paradi ^{[8
]}

Tosti, Antonella ^{[9
]}

Hordinsky, Maria ^{[10
]}

Huang, Kathie P. ^{[11
]}

Castelo-Soccio, Leslie ^{[12
]}

Bergfeld, Wilma ^{[13
]}

Paller, Amy S. ^{[14
]}

Mackay-Wiggan, Julian ^{[15
]}

Glashofer, Marc ^{[16
]}

Aguh, Crystal ^{[17
]}

Piliang, Melissa ^{[13
]}

Yazdan, Pedram ^{[14
]}

Lo Sicco, Kristen ^{[6
]}

Cassella, James, V ^{[18
]}

Koenigsberg, Justine ^{[18
]}

Ahluwalia, Gurpreet ^{[19
]}

Ghorayeb, Eric ^{[20
]}

Fakharzadeh, Steven ^{[20
]}

Napatalung, Lynne ^{[21
]}

Gandhi, Kavita ^{[21
]}

DeLozier, Amy M. ^{[22
]}

Nunes, Fabio P. ^{[20
,22
]}

Senna, Maryanne M. ^{[23
]}

机构：

[1] Yale Univ, Dept Dermatol, POB 208059, New Haven, CT 06520 USA

[2] Univ Calif Irvine, Dept Dermatol, Irvine, CA 92717 USA

[3] Howard Univ, Washington, DC 20059 USA

[4] Stanford Univ, Stanford, CA 94305 USA

[5] Wake Forest Baptist Hlth, Winston Salem, NC USA

[6] NYU, Langone Hlth, New York, NY USA

[7] Univ Calif Los Angeles, Los Angeles, CA USA

[8] Kaiser Permanente Vallejo Med Ctr, Vallejo, CA USA

[9] Univ Miami, Miami, FL USA

[10] Univ Minnesota, Minneapolis, MN USA

[11] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[12] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[13] Cleveland Clin, Cleveland, OH 44106 USA

[14] Northwestern Univ, Evanston, IL USA

[15] Columbia Univ, New York, NY USA

[16] Dermatol Grp, W Orange, NJ USA

[17] Johns Hopkins Univ, Baltimore, MD USA

[18] Concert Pharmaceut Inc, Lexington, MA USA

[19] Arena Pharmaceut Inc, San Diego, CA USA

[20] Janssen Global Serv LLC, Horsham, PA USA

[21] Pfizer, New York, NY USA

[22] Eli Lilly & Co, Indianapolis, IN 46285 USA

[23] Massachusetts Gen Hosp, Dermatol Associates, 50 Stanford St,2nd Floor, Boston, MA 02114 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2022年 / 86卷 / 02期

关键词：

alopecia areata; clinical practice; consensus; severity; DOUBLE-BLIND; LYMPHOCYTES;

D O I：

10.1016/j.jaad.2021.08.043

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: The current classification for alopecia areata (AA) does not provide a consistent assessment of disease severity. Objective: To develop an AA severity scale based on expert experience. Methods: A modified Delphi process was utilized. An advisory group of 22 AA clinical experts from the United States was formed to develop this AA scale. Representatives from the pharmaceutical industry provided feedback during its development. Results: Survey responses were used to draft severity criteria, aspiring to develop a simple scale that may be easily applied in clinical practice. A consensus vote was held to determine the final AA severity statement, with all AA experts agreeing to adopt the proposed scale. Limitations: The scale is a static assessment intended to be used in clinical practice and not clinical trials. Conclusion: The final AA disease severity scale, anchored in the extent of hair loss, captures key features commonly used by AA experts in clinical practice. This scale will better aid clinicians in appropriately assessing severity in patients with this common disease. ( J Am Acad Dermatol 2022;86:359-64.)

引用

页码：359 / 364

页数：6

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