Advances in Fluorescent Single-Chain Nanoparticles

被引：36
作者：
De-La-Cuesta, Julen [1 ,2 ]
Gonzalez, Edurne [1 ]
Pomposo, Jose A. [1 ,2 ,3 ]
机构：
[1] Univ Basque Country, CSIC, MPC, Ctr Fis Mat, Paseo Manuel Lardizabal 5, E-20018 San Sebastian, Spain
[2] Univ Basque Country, UPV EHU, Dept Fis Mat, 1072 Apartado, E-20080 San Sebastian, Spain
[3] Basque Fdn Sci, Ikerbasque, Maria Diaz Haro 3, E-48013 Bilbao, Spain
来源：
MOLECULES | 2017年 / 22卷 / 11期
关键词：
nanoparticles; fluorescence; optical imaging; ONE-POT SYNTHESIS; POLYMER NANOPARTICLES; POLYSTYRENE NANOPARTICLES; UNIMER NANOPARTICLES; POLY(AMINO ACID)S; CLICK CHEMISTRY; CROSS-LINKING; QUANTUM DOTS; WATER; CONSTRUCTION;
D O I：
10.3390/molecules22111819
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fluorophore molecules can be monitored by fluorescence spectroscopy and microscopy, which are highly useful and widely used techniques in cell biology, biochemistry, and medicine (e.g., biomarker analysis, immunoassays, cancer diagnosis). Several fluorescent micro- and nanoparticle systems based on block copolymer micelles and cross-linked polymer networks, quantum dots, -conjugated polymers, and dendrimers have been evaluated as optical imaging systems. In this review, we highlight recent advances in the construction of fluorescent single-chain nanoparticles (SCNPs), which are valuable artificial soft nano-objects with a small tunable size (as small as 3 nm). In particular, the main methods currently available to endow SCNPs with fluorescent properties are discussed in detail, showing illustrative examples.
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页数：14
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