Roles for the mycobiome in liver disease

被引：26

作者：

Zeng, Suling ^{[1
,2
]}

Schnabl, Bernd ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Med, MC0063,9500 Gilman Dr, La Jolla, CA 92093 USA

[2] VA San Diego Healthcare Syst, Dept Med, San Diego, CA USA

来源：

LIVER INTERNATIONAL | 2022年 / 42卷 / 04期

关键词：

alcohol-associated liver disease; cirrhosis; fungi; fungi-bacterial interaction; immune response; yeast; non-alcoholic fatty liver disease; HEPATOCELLULAR-CARCINOMA; INTESTINAL PERMEABILITY; FUNGAL-INFECTIONS; CANDIDA-ALBICANS; IMMUNITY; MANAGEMENT; BACTERIAL; EXPOSURE; RATS;

D O I：

10.1111/liv.15160

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver disease, a major cause of global mortality, has been associated with dysbiosis of the intestinal microbiota (bacteria, fungi, viruses, and other microbes). Studies have associated changes in gut bacteria with pathogenesis and severity of liver disease, but the contributions of the mycobiome (the fungal populations of the gut) to health and disease have not been well studied. We review recent findings of alterations in the composition of the mycobiota in patients with liver disease and discuss the mechanisms by which these might affect pathogenesis and disease progression. Strategies to manipulate the gut mycobiota might be developed to treat or prevent liver disease.

引用

页码：729 / 741

页数：13

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