A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

被引：36

作者：

Demizu, Yosuke ^{[1
,2
]}

Oba, Makoto ^{[3
]}

Okitsu, Koyo ^{[2
,4
]}

Yamashita, Hiroko ^{[2
,4
]}

Misawa, Takashi ^{[2
]}

Tanaka, Masakazu ^{[3
]}

Kurihara, Masaaki ^{[2
,4
]}

Gellman, Samuel H. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53707 USA

[2] Natl Inst Hlth Sci Setagaya, Tokyo 1588501, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

[4] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Yokohama, Kanagawa 2268501, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 20期

基金：

美国国家科学基金会;

关键词：

ALPHA-HELIX MIMICRY; INTRACELLULAR DELIVERY; POLYPLEX MICELLES; DESIGN; FOLDAMERS; MOLECULES; ANTIBACTERIAL; TRANSLOCATION; TRANSFECTION; TRANSPORTERS;

D O I：

10.1039/c5ob00389j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cyclic beta-amino acid (APC(Gu)) bearing a side-chain guanidinium group has been developed. The APC(Gu) residue was incorporated into an alpha/beta-peptide based on the Tat(47-57) fragment, leading to an oligomer with substantial helicity in methanol that enters HeLa cells much more readily than does the corresponding Tat alpha-peptide.

引用

页码：5617 / 5620

页数：4

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