Impulse Control Behaviors in Parkinson's Disease: Drugs or Disease? Contribution From Imaging Studies

被引：14

作者：

De Micco, Rosa ^{[1
,2
]}

Russo, Antonio ^{[1
,2
]}

Tedeschi, Gioacchino ^{[1
,2
]}

Tessitore, Alessandro ^{[1
,2
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Dept Med Surg Neurol Metab & Aging Sci, Naples, Italy

[2] Univ Campania Luigi Vanvitelli, MRI Res Ctr SUN FISM, Naples, Italy

来源：

FRONTIERS IN NEUROLOGY | 2018年 / 9卷

关键词：

Parkinson's disease; impulse control behaviors; MRI; PET; reward system; STRIATAL DOPAMINE RELEASE; RESTLESS LEGS SYNDROME; CONTROL DISORDERS; NEURAL RESPONSE; AGONIST THERAPY; BRAIN NETWORKS; REINFORCEMENT; CONNECTIVITY; HUMANS; MEDICATION;

D O I：

10.3389/fneur.2018.00893

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Impulse control behaviors (ICB) are recognized as non-motor complications of dopaminergic medications in patients with Parkinson's disease (PD). Compelling evidence suggests that ICB are not merely due to the PD-related pathology itself. Several risk factors have been identified, either demographic, clinical, genetic or neuropsychological. Neuroimaging studies have yielded controversial results regarding ICB correlates in PD and still it is not clear whether they can be triggered by the PD biology or the dopaminergic treatment stimulation. We provided an overview of the imaging studies that offered the most relevant insights into the debate about the role of drugs and disease in ICB pathophysiology. Understanding neural correlates and potential predisposing factors of these severe neuropsychiatric symptoms will be crucial to guide clinical practice and to foster preventive strategies.

引用

页数：7

共 52 条

[1] At-risk for pathological gambling: imaging neural reward processing under chronic dopamine agonists [J].