Potentiation of microglial endocannabinoid signaling alleviates neuroinflammation in Alzheimer's disease

被引：23

作者：

Rapaka, Deepthi ^{[1
]}

Bitra, Veera Raghavulu ^{[2
]}

Challa, Siva Reddy ^{[3
]}

Adiukwu, Paul C. ^{[2
]}

机构：

[1] Andhra Univ, AU Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India

[2] Univ Botswana, Sch Pharm, P Bag 0022, Gaborone, Botswana

[3] Univ Illinois, Dept Canc Biol & Pharmacol, Coll Med, Peoria, IL 61614 USA

来源：

NEUROPEPTIDES | 2021年 / 90卷

关键词：

Alzheimer's disease; Microglia; Endocannabinoid; Neuroinflammation; CB1R; CB2R; CANNABINOID CB2 RECEPTORS; ACID AMIDE HYDROLASE; CENTRAL-NERVOUS-SYSTEM; NEUROPATHIC PAIN; MOUSE MODEL; MONOACYLGLYCEROL LIPASE; COGNITIVE IMPAIRMENT; ALLOSTERIC MODULATOR; PROTECTS NEURONS; CONTROLLED-TRIAL;

D O I：

10.1016/j.npep.2021.102196

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease (AD) isaprogressive neurodegenerative disorder characterized by chronic inflammation due to the presence of neurotoxic A beta and tau proteins. Increased microglial activation and inflated immune response are the other factors to be considered in AD pathology. Microglial cells own biochemical machinery that synthesizes and release endocannabinoids. The exploitation of therapeutic actions of endocannabinoid system has newly emerged in the field of Alzheimer's disease. The activation of cannabinoid receptors/ cannabinoid system modulates inflammatory responses. This review assesses the association between the microglial endocannabinoid system and neuroinflammation in AD. The data supporting the anti-inflammatory role of pharmacological agents modulating cannabinoid system are also reviewed.

引用

页数：10

共 156 条

[1] Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor [J].

Abbassian, Hassan ;

Esmaeili, Parisa ;

Tahamtan, Mahshid ;

Aghaei, Iraj ;

Vaziri, Zohreh ;

Sheibani, Vahid ;

Whalley, Benjamin J. ;

Shabani, Mohammad .

PHYSIOLOGY & BEHAVIOR, 2016, 164 :314-320

[2] Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial [J].

不详 .

LANCET NEUROLOGY, 2008, 7 (01) :41-49

[3] Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression [J].

Adhikary, Sabina ;

Kocieda, Virginia P. ;

Yen, Jui-Hung ;

Tuma, Ronald F. ;

Ganea, Doina .

BLOOD, 2012, 120 (18) :3741-3749

[4] Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial [J].

Aisen, PS ;

Schafer, KA ;

Grundman, M ;

Pfeiffer, E ;

Sano, M ;

Davis, KL ;

Farlow, MR ;

Jin, S ;

Thomas, RG ;

Thal, LJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (21) :2819-2826

[5] A randomized controlled trial of prednisone in Alzheimer's disease [J].

Aisen, PS ;

Davis, KL ;

Berg, JD ;

Schafer, K ;

Campbell, K ;

Thomas, RG ;

Weiner, MF ;

Farlow, MR ;

Sano, M ;

Grundman, M ;

Thal, LJ .

NEUROLOGY, 2000, 54 (03) :588-593

[6] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[7] Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation [J].

Alhouayek, Mireille ;

Lambert, Didier M. ;

Delzenne, Nathalie M. ;

Cani, Patrice D. ;

Muccioli, Giulio G. .

FASEB JOURNAL, 2011, 25 (08) :2711-2721

[8] 2021 Alzheimer's disease facts and figures [J].

不详 .

ALZHEIMERS & DEMENTIA, 2021, 17 (03) :327-406

[9] The Endocannabinoid System as a Window Into Microglial Biology and Its Relationship to Autism [J].

Araujo, Daniel John ;

Tjoa, Karensa ;

Saijo, Kaoru .

FRONTIERS IN CELLULAR NEUROSCIENCE, 2019, 13

[10] The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS [J].

Arcuri, Cataldo ;

Mecca, Carmen ;

Bianchi, Roberta ;

Giambanco, Ileana ;

Donato, Rosario .

FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10

← 1 2 3 4 5 6 7 8 9 10 →