VEGF Polymorphisms Related to Higher Serum Levels of Protein Identify Patients with Hepatocellular Carcinoma

被引：7

作者：

Lopes Baitello, Maria Eduarda ^{[1
]}

Tenani, Graciele Domitila ^{[1
]}

Ferreira, Rafael Fernandes ^{[1
]}

Nogueira, Victor ^{[1
]}

de Souza Pinhel, Marcela Augusta ^{[1
]}

Martins Alves da Silva, Rita de Cassia ^{[2
]}

da Silva, Renato Ferreira ^{[3
]}

Fucuta, Patricia da Silva ^{[2
]}

de Godoy, Moacir Fernandes ^{[1
]}

Silva Souza, Doroteia Rossi ^{[1
]}

机构：

[1] Med Sch Sao Jose do Rio Preto FAMERP, Res Ctr Biochem & Mol Biol, Sao Jose Do Rio Preto, SP, Brazil

[2] FUNFARME FAMERP, HB Univ Med Ctr, Hepatol Unit, Sao Jose Do Rio Preto, SP, Brazil

[3] FUNFARME FAMERP, HB Univ Med Ctr, Liver Transplantat Unit, Sao Jose Do Rio Preto, SP, Brazil

来源：

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2016年 / 2016卷

基金：

巴西圣保罗研究基金会;

关键词：

ENDOTHELIAL-GROWTH-FACTOR; FACTOR GENE POLYMORPHISMS; CANCER-RISK; ASSOCIATION; ALCOHOL; EPIDEMIOLOGY; DIAGNOSIS; SURVIVAL; TOBACCO;

D O I：

10.1155/2016/9607054

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatocellular carcinoma (HCC) is the most common primary neoplasia of the liver. Major risk factors for hepatocellular carcinoma include chronic liver diseases, carcinogenic agents, and genetic alterations as well as vascular endothelial growth factor (VEGF) involved in angiogenesis process. The aim of this study was to evaluate the association of VEGF-A(C936T and A1154G) with HCC and cirrhosis, in addition to serum levels of VEGF, clinical profile, lifestyle habits, and comorbidities. A total of 346 individuals were studied: 102 with HCC (G1), 117 with cirrhosis (G2), and 127 controls (G3). Polymorphisms were analysed by PCR/RFLP and serum levels of VEGF by ELISA. Alpha error was set at 5%. The wild-type genotype of both polymorphisms prevailed (P > 0.05). In G1, 23% of the patients died, with no relation to genetic profile (P > 0.05). Increased VEGF level was observed in G1 and G3, related to the mutant allele of VEGF-C936T and VEGF-A1154G, respectively, and compared with the wild-type genotype (P = 0.0285; P = 0.0284, resp.) as well as G1 versus G2 and G3 for VEGF-C936T and G1 versus G2 for VEGF-A1154G (P < 0.05 for both). In conclusion, there is a relationship between mutant alleles of VEGF-C936T and VEGF-A1154G polymorphisms and higher VEGF level, making them potential markers for HCC.

引用

页数：9

共 43 条

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