Facile expeditious one-pot synthesis and antifungal evaluation of disubstituted 1,2,3-triazole with two amide linkages

被引：7
|
作者：
Kaushik, C. P. [1 ]
Luxmi, Raj [1 ]
机构：
[1] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar 125001, Haryana, India
来源：
SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 23期
关键词：
1; 3-Dipolar cycloaddition; 4-disubstituted; 2; 3-triazoles; antifungal activity; synthesis; LINKED 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; ALKYNE CYCLOADDITION REACTIONS; CLICK CHEMISTRY; ANTIMICROBIAL EVALUATION; REGIOSELECTIVE SYNTHESIS; MATERIAL SCIENCE; DERIVATIVES; TRIAZOLE; AZIDE; 1,2,3-BISTRIAZOLES;
D O I：
10.1080/00397911.2017.1369124
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A library of twenty five amide linked 1,4-disubstituted 1,2,3-triazoles have been prepared through a facile expeditious synthetic protocol involving Cu(I) mediated cyclization of N-(2-methylbut-3-yn-2-yl)aromatic amides and in situ generated 2-azido-N-substituted propanamides. Structures of newly synthesized compounds (5a-5y) were confirmed by analytical techniques, such as FTIR, H-1 NMR, C-13 NMR, and HRMS. In vitro antifungal activity was also examined against two fungal strains Candida albicans and Aspergillus niger by serial dilution method. The compounds 5m and 5w exhibited appreciable potent activity. [GRAPHICS] .
引用
收藏
页码：2225 / 2231
页数：7
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