Assessing drug elution technologies in the superficial femoral artery

被引:0
作者
Owens, C. D. [1 ]
Gasper, W. J. [1 ]
Conte, M. S. [1 ]
机构
[1] Univ Calif San Francisco, Div Vasc & Endovasc Surg, San Francisco, CA 94143 USA
关键词
Femoral artery; Drug eluting stents; Drug delivery systems; IN-STENT RESTENOSIS; BARE NITINOL STENTS; BALLOON ANGIOPLASTY; SLOW-RELEASE; NEOINTIMAL PROLIFERATION; FEMOROPOPLITEAL ARTERIES; LOCAL-DELIVERY; SIROLIMUS; PACLITAXEL; IMPLANTATION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The endovascular management of symptomatic atherosclerotic superficial femoral artery (SFA) disease is challenging and requires consideration of unique anatomical, hemodynamic, and biomechanical factors. The current armamentarium of balloon catheters and flexible nitinol bare metal stents have limited long-term efficacy due to intimal hyperplasia resulting in restenosis. Unfortunately, the remarkably low restenosis rates achieved with drug eluting stents placed in the coronary vasculature has not been replicated in the femoral artery. The reason for this is multifactorial including delivery platforms, drug and dosage selection and trial design flaws. Currently, however, there are several novel therapies and delivery platforms in the development pipeline that have exhibited biologic effectiveness in preclinical and early clinical trials. While these offer promise in improving outcomes following lower extremity intervention, caution is warranted until the safety of these new technologies can be ensured.
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页码:37 / 49
页数:13
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