Physiology and relevance of human adaptive thermogenesis response

被引：46
作者：
Celi, Francesco S. [1 ]
Le, Trang N. [1 ]
Ni, Bin [1 ]
机构：
[1] Virginia Commonwealth Univ, Div Endocrinol & Metab, Dept Internal Med, Sch Med, Richmond, VA 23298 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2015年 / 26卷 / 05期
关键词：
adaptive thermogenesis; brown adipose tissue; humans; BROWN ADIPOSE-TISSUE; DIET-INDUCED THERMOGENESIS; BODY ENERGY-EXPENDITURE; COLD-EXPOSURE; BETA(3)-ADRENERGIC RECEPTOR; NONSHIVERING THERMOGENESIS; OUTDOOR TEMPERATURE; INSULIN SENSITIVITY; GENETIC-VARIATION; METABOLIC-RATE;
D O I：
10.1016/j.tem.2015.03.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In homoeothermic organisms, the preservation of core temperature represents a primal function, and its costs in terms of energy expenditure can be considerable. In modern humans, the endogenous thermoregulation mechanisms have been replaced by clothing and environmental control, and the maintenance of thermoneutrality has been successfully achieved by manipulation of the micro- and macroenvironment. The rediscovery of the presence and activity of brown adipose tissue in adult humans has renewed the interest on adaptive thermogenesis (AT) as a means to facilitate weight loss and improve carbohydrate metabolism. The aim of this review is to describe the recent advancements in the study of this function, and to assess the potential and limitations of exploiting AT for environmental/behavioral, and pharmacological interventions.
引用
收藏
页码：238 / 247
页数：10
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