Vitamins, minerals, essential fatty acids and colorectal cancer risk in the United Kingdom Dietary Cohort Consortium

被引：47

作者：

Key, Timothy J. ^{[1
]}

Appleby, Paul N. ^{[1
]}

Masset, Gabriel ^{[2
]}

Brunner, Eric J. ^{[2
]}

Cade, Janet E. ^{[3
]}

Greenwood, Darren C. ^{[3
]}

Stephen, Alison M. ^{[4
]}

Kuh, Diana ^{[5
]}

Bhaniani, Amit ^{[6
]}

Powell, Natasha ^{[6
]}

Khaw, Kay-Tee ^{[6
]}

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Clin Med, Oxford OX3 7LF, England

[2] UCL, Dept Epidemiol & Publ Hlth, London, England

[3] Univ Leeds, Ctr Biostat & Epidemiol, Leeds, W Yorkshire, England

[4] Elsie Widdowson Lab, Med Res Council Human Nutr Res, Cambridge, England

[5] UCL, MRC, Dept Epidemiol & Publ Hlth, Unit Lifelong Hlth & Ageing, London, England

[6] Univ Cambridge, MRC, Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2012年 / 131卷 / 03期

基金：

英国医学研究理事会;

关键词：

prospective; food diary; vitamins; minerals; essential fatty acids; colorectal cancer; METAANALYSIS; WOMEN; FISH; N-3; CHINESE; IRON; MEN;

D O I：

10.1002/ijc.27386

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The risk for colorectal cancer may be influenced by the dietary intake of various vitamins, minerals and essential fatty acids. We conducted a pooled analysis of dietary data collected using food diaries in seven prospective studies in the United Kingdom Dietary Cohort Consortium. Five hundred sixty-five cases of colorectal cancer were matched with 1,951 controls on study centre, age, sex and recruitment date. Dietary intakes of retinol, vitamin A, thiamin, riboflavin, vitamin B6, folate, vitamin B12, vitamin D, calcium, iron, magnesium, potassium, n - 6 fatty acids, n - 3 fatty acids and the ratio of n - 6 to n - 3 fatty acids were estimated and their associations with colorectal cancer examined using conditional logistic regression models, adjusting for exact age, height, weight, energy intake, alcohol intake, fiber intake, smoking, education, social class and physical activity. There were no statistically significant associations between colorectal cancer risk and dietary intake of any of the vitamins, minerals or essential fatty acids examined.

引用

页码：E320 / E325

页数：6