Traumatic brain injury (TBI) is a potentially preventable cause of epilepsy. Increasing incidence among army personnel and the high incidence among children and young people raise concern. This article presents a review of selected studies dealing with the risks of TBI and the risk of posttraumatic epilepsy in humans. The incidence of persons admitted to hospital with TBI has decreased in developed countries in recent years. However, there is little change in TBI-associated deaths, and the decrease in hospitalization may merely reflect that more people with head injury are cared for on an outpatient basis. It is clear that epilepsy is a frequent consequence of brain injury, even many years after the injury. However, several well-controlled studies have been unable to identify therapies that prevent the development of epilepsy after TBI. Posttraumatic epilepsy has significant implications for the affected individuals, family, and society. Despite several interventions used to prevent posttraumatic epilepsy, the only proven intervention to date is to prevent TBI from occurring.
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Mario Negri Inst Pharmacol Res, I-20157 Milan, ItalyColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Beghi, Ettore
Carpio, Arturo
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Univ Cuenca, Dept Neurol, Cuenca, EcuadorColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Carpio, Arturo
Forsgren, Lars
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Umea Univ, Dept Neurol, S-90187 Umea, SwedenColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Forsgren, Lars
Hesdorffer, Dale C.
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Columbia Univ, Dept Neurol, New York, NY 10032 USAColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Hesdorffer, Dale C.
Malmgren, Kristina
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Univ Gothenburg, Gothenburg, SwedenColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Malmgren, Kristina
Sander, Josemir W.
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UCL Inst Neurol, London, England
Netherlands Fdn, Epilepsy Inst, SEIN, Heemstede, NetherlandsColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Sander, Josemir W.
Tomson, Torbjorn
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Karolinska Inst, Stockholm, SwedenColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Tomson, Torbjorn
Hauser, W. Allen
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机构:
Columbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Columbia Univ, Dept Neurol, New York, NY 10032 USAColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
机构:
Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Ferguson, Pamela L.
Smith, Gigi M.
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Med Univ S Carolina, Dept Neurol, Charleston, SC 29425 USA
Med Univ S Carolina, Coll Nursing, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Smith, Gigi M.
Wannamaker, Braxton B.
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Med Univ S Carolina, Dept Neurol, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Wannamaker, Braxton B.
Thurman, David J.
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Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Thurman, David J.
Pickelsimer, E. Elisabeth
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Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Pickelsimer, E. Elisabeth
Selassie, Anbesaw W.
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Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
机构:
Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA
Univ Washington, Harborview Med Ctr, Reg Epilepsy Ctr, Seattle, WA 98104 USA
Univ Washington, Med Ctr, Seattle, WA 98195 USAGeisinger Med Ctr, Dept Neurosurg, Danville, PA 17822 USA
机构:
Mario Negri Inst Pharmacol Res, I-20157 Milan, ItalyColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Beghi, Ettore
Carpio, Arturo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cuenca, Dept Neurol, Cuenca, EcuadorColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Carpio, Arturo
Forsgren, Lars
论文数: 0引用数: 0
h-index: 0
机构:
Umea Univ, Dept Neurol, S-90187 Umea, SwedenColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Forsgren, Lars
Hesdorffer, Dale C.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Neurol, New York, NY 10032 USAColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Hesdorffer, Dale C.
Malmgren, Kristina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Gothenburg, Gothenburg, SwedenColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Malmgren, Kristina
Sander, Josemir W.
论文数: 0引用数: 0
h-index: 0
机构:
UCL Inst Neurol, London, England
Netherlands Fdn, Epilepsy Inst, SEIN, Heemstede, NetherlandsColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Sander, Josemir W.
Tomson, Torbjorn
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Stockholm, SwedenColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Tomson, Torbjorn
Hauser, W. Allen
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
Columbia Univ, Dept Neurol, New York, NY 10032 USAColumbia Univ, Gertrude H Sergievsky Ctr, Dept Epidemiol, P&S Unit 16, New York, NY 10032 USA
机构:
Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Ferguson, Pamela L.
Smith, Gigi M.
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ S Carolina, Dept Neurol, Charleston, SC 29425 USA
Med Univ S Carolina, Coll Nursing, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Smith, Gigi M.
Wannamaker, Braxton B.
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ S Carolina, Dept Neurol, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Wannamaker, Braxton B.
Thurman, David J.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Thurman, David J.
Pickelsimer, E. Elisabeth
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
Pickelsimer, E. Elisabeth
Selassie, Anbesaw W.
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USAMed Univ S Carolina, Div Biostat & Epidemiol, Dept Med, Charleston, SC 29425 USA
机构:
Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA
Univ Washington, Harborview Med Ctr, Reg Epilepsy Ctr, Seattle, WA 98104 USA
Univ Washington, Med Ctr, Seattle, WA 98195 USAGeisinger Med Ctr, Dept Neurosurg, Danville, PA 17822 USA