Agitated delirium associated with therapeutic doses of sustained-release bupropion

被引:6
作者
Mack, Diana R. [1 ]
Barbarello-Andrews, Liza [2 ]
Liu, Mei T. [2 ]
机构
[1] Virginia Commonwealth Univ, Dept Pharmacotherapy & Outcomes Sci, Sch Pharm, Richmond, VA 23298 USA
[2] Rutgers State Univ, Univ Med Ctr Princeton, Ernest Mario Sch Pharm, Piscataway, NJ 08854 USA
关键词
Agitation; Adverse drug events; Bupropion; Delirium; Psychosis; ACUTE-PSYCHOSIS; MANAGEMENT;
D O I
10.1007/s11096-011-9587-x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Case description We report a case of a patient initiated on therapeutic doses of sustained-release bupropion for the management of major depressive disorder who subsequently developed acute agitated delirium that required ICU level care. This patient's history was significant for alcohol and cannabis abuse but he was currently detoxified and beyond the withdrawal period. Throughout the course of treatment, all maintenance medications, including bupropion, were discontinued and the patient required escalating doses of benzodiazepines and typical antipsychotics to resolve symptoms. The patient's delirium subsided after approximately 5 days. Conclusion Dopamine is thought to play a role in the pathophysiology of delirium and given the mechanism of action of this drug and the presence of delirium risk factors in our patient, we are faced with a likely causative factor of this acute delirious episode.
引用
收藏
页码:9 / 12
页数:4
相关论文
共 12 条
[1]   Acute psychosis after bupropion treatment in a healthy 28-year-old woman [J].
Bailey, Justin ;
Waters, Shannon .
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE, 2008, 21 (03) :244-245
[2]   Delirium associated with concomitant use of low-dose bupropion sustained release and fluoxetine [J].
Chan, Chia Hsiang ;
Liu, Hsing Cheng ;
Huang, Ming Chyi .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2006, 26 (06) :677-679
[3]  
GlaxoSmithKline, 2007, WELLB SR BUPR SR PAC
[4]  
Hahn Margaret, 2007, J Psychiatr Pract, V13, P336, DOI 10.1097/01.pra.0000290673.32978.e8
[5]  
Howard WT, 1999, AM J PSYCHIAT, V156, P2017
[6]   Two acute psychotic episodes after administration of bupropion: a case of involuntary rechallenge [J].
Javelot, Herve ;
Baratta, Alexandre ;
Weiner, Luisa ;
Javelot, Thierry ;
Nonnenmacher, Cathy ;
Westphal, Jean Frederic ;
Messaoudi, Michael .
PHARMACY WORLD & SCIENCE, 2009, 31 (02) :238-240
[7]  
LIBERZON I, 1990, AM J PSYCHIAT, V147, P1689
[8]   Drug therapy - The medical management of depression [J].
Mann, JJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1819-1834
[9]   Regular review - Delirium: optimising management [J].
Meagher, DJ .
BMJ-BRITISH MEDICAL JOURNAL, 2001, 322 (7279) :144-149
[10]   Acute psychosis after administration of bupropion hydrochloride (Zyban™) [J].
Neumann, M ;
Livak, V ;
Paul, HM ;
Laux, G .
PHARMACOPSYCHIATRY, 2002, 35 (06) :247-248