Solvent dependence of helix stability in aromatic oligoamide foldamers

被引：89

作者：

Qi, Ting ^{[1
,2
]}

Maurizot, Victor ^{[1
,2
]}

Noguchi, Hiroki ^{[3
]}

Charoenraks, Thiraporn ^{[3
]}

Kauffmann, Brice ^{[4
,5
,6
]}

Takafuji, Makoto ^{[3
]}

Ihara, Hirotaka ^{[3
]}

Huc, Ivan ^{[1
,2
]}

机构：

[1] Univ Bordeaux, CBMN, UMR 5248, Inst Europeen Chim & Biol, F-33600 Pessac, France

[2] CNRS, CBMN, UMR 5248, Inst Europeen Chim & Biol, F-33600 Pessac, France

[3] Kumamoto Univ, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan

[4] Univ Bordeaux, IECB, UMS 3033, F-33600 Pessac, France

[5] CNRS, IECB, UMS 3033, F-33600 Pessac, France

[6] INSERM, IECB, US 0001, F-33600 Pessac, France

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 51期

关键词：

ALPHA-HELICITY; OLIGOMERS; TRIFLUOROETHANOL; HANDEDNESS; WATER;

D O I：

10.1039/c2cc31533e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new helical aromatic oligoamide foldamer, bearing triethyleneglycol side chains for solubility in a broad range of media, was prepared. The stability of the helical conformation was assessed in various solvents and shown to vary greatly and unexpectedly. Stability was remarkably enhanced in methanol-water mixtures.

引用

收藏

页码：6337 / 6339

页数：3

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