Life factors acting on systemic lupus erythematosus

被引：19

作者：

Chen, Jiaxuan ^{[1
]}

Liao, Shuzhen ^{[1
]}

Pang, Wanxian ^{[1
]}

Guo, Fengbiao ^{[1
]}

Yang, Lawei ^{[1
]}

Liu, Hua-feng ^{[1
]}

Pan, Qingjun ^{[1
]}

机构：

[1] Guangdong Med Univ, Guangdong Prov Key Lab Autophagy & Major Chron Non, Affiliated Hosp, Zhanjiang, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

systemic lupus erythematosus; lifestyle; diet; smoking; alcohol; ultraviolet radiation; VITAMIN-D DEFICIENCY; DIETARY FISH-OIL; POLYUNSATURATED FATTY-ACIDS; ATTENUATES KIDNEY-DISEASE; CD4(+) T-CELLS; CIGARETTE-SMOKING; ALCOHOL-CONSUMPTION; EICOSAPENTAENOIC ACID; RISK-FACTORS; RHEUMATOID-ARTHRITIS;

D O I：

10.3389/fimmu.2022.986239

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. Currently, in the search for the mechanisms of SLE pathogenesis, the association of lifestyle factors such as diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption with SLE susceptibility has been systematically investigated. The cellular and molecular mechanisms mediating lifestyle effects on SLE occurrence, including interactions between genetic risk loci and environment, epigenetic changes, immune dysfunction, hyper-inflammatory response, and cytotoxicity, have been proposed. In the present review of the reports published in reputable peer-reviewed journals and government websites, we consider the current knowledge about the relationships between lifestyle factors and SLE incidence and outline directions of future research in this area. Formulation of practical measures with regard to the lifestyle in the future will benefit SLE patients and may provide potential therapy strategies.

引用

页数：10