Induction of apoptosis by erucylphospho-N,N,N-trimethylammonium is associated with changes in signal molecule expression and location

被引：20

作者：

Berger, MR

Tsoneva, I

Konstantinov, SM

Eibl, H

机构：

[1] German Canc Res Ctr, Unit Toxicol & Chemotherapy, D-69120 Heidelberg, Germany

[2] BAS, Inst Biophys, BU-1113 Sofia, Bulgaria

[3] Med Univ Sofia, Dept Pharmacol, Lab Expt Chemotherapy, BU-1000 Sofia, Bulgaria

[4] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany

来源：

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷

关键词：

alkylphosphocholine; mechanism of action; modulation of signal molecules; lipid rafts;

D O I：

10.1196/annals.1299.054

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at least part of its antineoplastic activity by apoptosis, and this chain of events comprises early changes in the lipid raft fraction of the cellular membrane as well as modulation of different signal molecules, such as Abl, Bcr-Abl (fusion protein), and Rb.

引用

页码：307 / 310

页数：4