DNA methylation and genetic instability in colorectal cancer cells

被引：327

作者：

Lengauer, C ^{[1
]}

Kinzler, KW ^{[1
]}

Vogelstein, B ^{[1
]}

机构：

[1] JOHNS HOPKINS ONCOL CTR,HOWARD HUGHES MED INST,BALTIMORE,MD 21231

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 06期

关键词：

D O I：

10.1073/pnas.94.6.2545

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Apparent alterations in DNA methylation have been observed in many cancers, but whether such alterations represent a persistent alteration in the normal methylation process is not known. In this study, we report a striking difference in the expression of exogenously introduced retroviral genes in various colorectal cancer cell lines. Extinguished expression was associated with DNA methylation and could be reversed by treatment with the demethylating agent 5-azacytidine. A striking correlation between genetic instability and methylation capacity suggested that methylation abnormalities may play a role in chromosome segregation processes in cancer cells.

引用

页码：2545 / 2550

页数：6

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