The role of advanced glycation end products in human infertility

被引：24
|
作者：
Zhu, Jing-Ling [1 ,2 ,3 ,4 ]
Cai, Ya-qin [3 ,4 ]
Long, Shuang-lian [1 ,2 ]
Chen, Zhuo [1 ,2 ]
Mo, Zhong-cheng [3 ]
机构：
[1] Univ South China, Hunan Prov Innovat Training Base Med Postgrad, Yueyang 416000, Hunan, Peoples R China
[2] Yueyang Women & Childrens Med Ctr, Yueyang 416000, Hunan, Peoples R China
[3] Guilin Med Univ, Inst Basic Med Sci, Ctr Diabet Syst Med, Guangxi Key Lab Excellence, Guilin 541199, Guangxi, Peoples R China
[4] Univ South China, Hengyang Med Sch, Dept Histol & Embryol, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China
来源：
LIFE SCIENCES | 2020年 / 255卷
关键词：
POLYCYSTIC-OVARY-SYNDROME; FOLLICLE-STIMULATING-HORMONE; INCREASED OXIDATIVE STRESS; SOLUBLE RECEPTOR; DIETARY GLYCOTOXINS; INSULIN-RESISTANCE; ANTIOXIDANT STATUS; CARBONYL STRESS; LYSYL OXIDASE; GROWTH-FACTOR;
D O I：
10.1016/j.lfs.2020.117830
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approximately 10 to15% of couples of reproductive ages. AGEs accumulation has been shown to play a crucial role in pathogenesis of infertility-related diseases. The present review provides the generation process, mechanism and pathological significance of AGEs and the novel treatment targeting AGEs for infertility. © 2020
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页数：10
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