FGFR2 gene polymorphisms are associated with breast cancer risk in the Han Chinese population

被引：0
|
作者：
Xia, Peng [1 ,2 ,3 ]
Li, Bin [4 ]
Geng, Tingting [3 ,5 ]
Deng, Zhiping [1 ]
Dang, Chengxue [1 ]
Chang, Dongmin [1 ]
Kang, Longli [6 ,7 ]
Jin, Tianbo [2 ,3 ,5 ]
Chen, Chao [2 ,3 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Oncol, Xian 710061, Peoples R China
[2] NW Univ Xian, Sch Life Sci, Xian 710069, Peoples R China
[3] Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Peoples R China
[4] Xian Med Coll, Affiliated Hosp 1, Dept Oncol, Xian 710077, Peoples R China
[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian 710069, Peoples R China
[6] Xizang Minzu Univ, Sch Med, Key Lab High Altitude Environm & Genes Related Di, Xianyang 712082, Peoples R China
[7] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2015年 / 5卷 / 05期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Single nucleotide polymorphism (SNP); breast cancer; FGFR2; case-control studies; GENOME-WIDE ASSOCIATION; PROGESTERONE-RECEPTOR STATUS; ESTROGEN-RECEPTOR; SUSCEPTIBILITY LOCI; ALLELES; WOMEN;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aims and background: Breast cancer is one of the most common neoplasms among women in many developing countries including China, and is the leading cause of female cancer-related deaths worldwide. Methods: In the current study, we analyzed the relationship between 14 tag single-nucleotide polymorphisms (tSNPs) and breast cancer risk in the Han Chinese population including 185 breast cancer patients and 199 healthy women controls on the different types of breast cancer and menopausal status. Results: Overall, we found rs2981579 in the FGFR2 gene, and rs2380205 were associated with breast cancer susceptibility.
引用
收藏
页码：1854 / 1861
页数：8
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