Clostridium perfringens beta toxin and Clostridium septicum alpha toxin:: their mechanisms and possible role in pathogenesis

被引：52

作者：

Tweten, RK ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73190 USA

来源：

VETERINARY MICROBIOLOGY | 2001年 / 82卷 / 01期

关键词：

Clostridium perfringens; Clostridium septicum; toxins;

D O I：

10.1016/S0378-1135(01)00372-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Clostridium septicum alpha toxin and the Clostridium perfringens beta toxin are examples of pore-forming toxins that exhibit several different features. The cell types that are targeted by these toxins reflect the effect these toxins have on the host during infection with either organism. Alpha toxin elicits a rapid shock-like syndrome, whereas beta toxin appears to induce a variety of neurological effects. The effects of the purified toxins appear to mimic some of the features of the animal and human diseases caused by C. septicum and C. perfringens. This review, examines the current state of knowledge for the cytolytic mechanism, role in pathogenesis and structure of these two toxins. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 9

页数：9