High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix

被引：57
作者：
Gramaglia, D
Conway, BR
Kett, VL
Malcolm, RK
Batchelor, HK [1 ]
机构：
[1] Aston Univ, Med Res Unit, Birmingham B4 7ET, W Midlands, England
[2] Univ Pavia, Dept Pharmaceut Chem, I-27100 Pavia, Italy
[3] Queens Univ Belfast, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 301卷 / 1-2期
关键词：
high-speed DSC; solubility; metronidazole; silicone;
D O I：
10.1016/j.ijpharm.2005.04.038
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Conventional differential scanning calorimetry (DSC) techniques are commonly used to quantify the solubility of drugs within polymeric-controlled delivery systems. However, the nature of the DSC experiment, and in particular the relatively slow heating rates employed, limit its use to the measurement of drug solubility at the drug's melting temperature. Here, we describe the application of hyper-DSC (HDSC), a variant of DSC involving extremely rapid heating rates, to the calculation of the solubility of a model drug, metronidazole, in silicone elastomer, and demonstrate that the faster heating rates permit the solubility to be calculated under non-equilibrium conditions such that the solubility better approximates that at the temperature of use. At a heating rate of 400 degrees C/min (HDSC), metronidazole solubility was calculated to be 2.16 mg/g compared with 6.16 mg/g at 20 degrees C/min. (C) 2005 Elsevier B.V. All rights reserved.
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页码：1 / 5
页数：5
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