Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration

被引：2

作者：

Takamiya, Akihiro ^{[1
,2
]}

Dols, Annemiek ^{[3
,4
]}

Emsell, Louise ^{[2
]}

Abbott, Christopher ^{[5
]}

Yrondi, Antoine ^{[6
]}

Mas, Carles Soriano ^{[7
,8
,9
]}

Jorgensen, Martin Balslev ^{[10
,11
]}

Nordanskog, Pia ^{[12
]}

Rhebergen, Didi ^{[13
]}

van Exel, Eric ^{[3
,4
]}

Oudega, Mardien L. ^{[3
,4
]}

Bouckaert, Filip ^{[2
]}

Vandenbulcke, Mathieu ^{[2
]}

Sienaert, Pascal ^{[14
]}

Peran, Patrice ^{[15
]}

Cano, Marta ^{[8
,9
,16
]}

Cardoner, Narcis ^{[16
]}

Jorgensen, Anders ^{[10
,11
]}

Paulson, Olaf B. ^{[17
]}

Hamilton, Paul ^{[18
]}

Kampe, Robin ^{[18
]}

Bruin, Willem ^{[19
]}

Bartsch, Hauke ^{[20
,21
,22
]}

Ousdal, Olga Therese ^{[20
,23
]}

Kessler, Ute ^{[24
,25
]}

van Wingen, Guido ^{[19
]}

Oltedal, Leif ^{[20
,24
]}

Kishimoto, Taishiro ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan

[2] Katholieke Univ Leuven, Leuven Brain Inst, Dept Neurosci & Neuropsychiat, Leuven, Belgium

[3] GGZ InGeest Specialized Mental Hlth Care, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam Neurosci, Amsterdam, Netherlands

[5] Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA

[6] Univ Toulouse, CHU Toulouse,Hosp Purpan,UPS,Inserm, Serv Psychiat & Psychol Med,Toulouse NeuroImaging, ToNIC,Ctr Expert Depress Resistante FondaMental, Toulouse, France

[7] Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Barcelona, Spain

[8] Carlos III Hlth Inst, CIBERSAM, Madrid, Spain

[9] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain

[10] Psychiat Ctr Copenhagen, Copenhagen, Denmark

[11] Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark

[12] Linkoping Univ, Ctr Social & Affect Neurosci CSAN, Dept Clin & Expt Med, Linkoping, Sweden

[13] GGZ Centraal, Mental Hlth Care Inst, Amersfoort, Netherlands

[14] Katholieke Univ Leuven, Univ Psychiat Ctr UPC, Acad Ctr ECT & Neurostimulat AcCENT, Kortenberg, Belgium

[15] Univ Toulouse, Toulouse NeuroImaging Ctr, UPS, INSERM,ToNIC, Toulouse, France

[16] Parc Tauli Univ Hosp, Inst Invest & Innovacio Sanitaria Parc Tauli I3PT, Unitat Neurociencia Traslac, Mental Hlth Dept, Barcelona, Spain

[17] Rigshosp, Neurobiol Res Unit, Copenhagen, Denmark

[18] Linkoping Univ, Ctr Social & Affect Neurosci CSAN, Dept Biomed & Clin Sci, Linkoping, Sweden

[19] Amsterdam UMC, Dept Psychiat, Amsterdam Neurosci, Amsterdam, Netherlands

[20] Haukeland Hosp, Mohn Med Imaging & Visualizat Ctr, Dept Radiol, Bergen, Norway

[21] Haukeland Hosp, Dept Res & Innovat, Bergen, Norway

[22] Univ Bergen, Dept Informat, Bergen, Norway

[23] Univ Bergen, Fac Psychol, Ctr Crisis Psychol, Bergen, Norway

[24] Univ Bergen, Dept Clin Med, Bergen, Norway

[25] Haukeland Hosp, Div Psychiat, NORMENT, Bergen, Norway

来源：

SCHIZOPHRENIA BULLETIN | 2022年 / 48卷 / 02期

关键词：

psychosis; depression; magnetic resonance imaging; gray matter volume; medial prefrontal cortex; MEDIAL PREFRONTAL CORTEX; DEFAULT-MODE NETWORK; ELECTROCONVULSIVE-THERAPY; MAJOR DEPRESSION; LATE-LIFE; HIPPOCAMPAL VOLUME; MOOD DISORDERS; BRAIN; CORTISOL; REMISSION;

D O I：

10.1093/schbul/sbab122

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.

引用

页码：514 / 523

页数：10

共 31 条

[31] Role of palmitoylethanolamide (PEA) in depression: Translational evidence Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders
De Gregorio, Danilo
Manchia, Mirko
Carpiniello, Bernardo
Valtorta, Flavia
Nobile, Maria
Gobbi, Gabriella
Comai, Stefano
JOURNAL OF AFFECTIVE DISORDERS, 2019, 255 : 195 - 200

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