Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma

被引：70
|
作者：
Stanczak, Aleksandra [1 ,2 ]
Stec, Rafal [3 ]
Bodnar, Lubomir [3 ]
Olszewski, Wojciech [4 ]
Cichowicz, Marzena [5 ]
Kozlowski, Wojciech [5 ]
Szczylik, Cezary [3 ]
Pietrucha, Tadeusz [2 ]
Wieczorek, Maciej [1 ]
Lamparska-Przybysz, Monika [1 ]
机构：
[1] Celon Pharma Ltd, Innovat Drugs Res & Dev Dept, PL-05092 Lomianki, Poland
[2] Med Univ Lodz, Dept Med Biotechnol, Lodz, Poland
[3] Mil Inst Hlth Serv Warsaw, Dept Oncol, Warsaw, Poland
[4] Inst Oncol, Dept Pathol, Warsaw, Poland
[5] Mil Inst Hlth Serv Warsaw, Dept Pathol, Warsaw, Poland
来源：
PATHOLOGY & ONCOLOGY RESEARCH | 2011年 / 17卷 / 04期
关键词：
beta-catenin; E-cadherin; Wnt-1; Wnt signaling pathway; Advanced colorectal carcinoma; Prognostic factor; POLYPOSIS-COLI PATIENTS; LIVER METASTASIS; GENE-MUTATIONS; TUMOR-MARKERS; CANCER; APC; SURVIVAL; PATHWAY; IDENTIFICATION; MECHANISMS;
D O I：
10.1007/s12253-011-9409-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Wnt/beta-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, beta-catenin and Wnt-1 proteins in colorectal tumors. Expression of beta-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, beta-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear beta-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/beta-catenin pathway plays an important role in advanced colorectal carcinoma.
引用
收藏
页码：955 / 963
页数：9
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