Lighting up the tumor fire with low-dose irradiation

被引：31
作者：
Herrera, Fernanda G. [1 ,2 ,3 ]
Romero, Pedro [1 ,3 ]
Coukos, George [1 ,3 ]
机构：
[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, Lausanne, Switzerland
[2] Lausanne Univ Hosp, Dept Oncol, Radiat Oncol Serv, Lausanne, Switzerland
[3] Lausanne Univ Hosp, Dept Oncol, Immunooncol Serv, Lausanne, Switzerland
来源：
TRENDS IN IMMUNOLOGY | 2022年 / 43卷 / 03期
关键词：
CD8(+) T-CELLS; CALRETICULIN EXPOSURE; ANTICANCER CHEMOTHERAPY; RADIOTHERAPY; IMMUNITY; MECHANISMS; RESPONSES; MICROENVIRONMENT; IMMUNOGENICITY; BLOCKADE;
D O I：
10.1016/j.it.2022.01.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Current efforts combining immunotherapy and radiation have focused on high-dose radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; however, these effects are uncommon in patients. Three recent studies in mouse tumor models and human cancer patients show that low-dose radiation (LDRT) delivered to all tumor lesions effectively mobilizes innate and adaptive immunity and synergizes with immunotherapy. These new findings suggest LDRT's potential as an immune amplifier capable of reprogramming the tumor microenvironment, instigating inflammation, and sensitizing 'cold' tumors to immune checkpoint blockade responsiveness.
引用
收藏
页码：173 / 179
页数：7
相关论文
共 50 条
  • [41] Sequential Low-Dose Rate Half-Body Irradiation and Chemotherapy for the Treatment of Canine Multicentric Lymphoma
    Lurie, D. M.
    Gordon, I. K.
    Theon, A. P.
    Rodriguez, C. O.
    Suter, S. E.
    Kent, M. S.
    JOURNAL OF VETERINARY INTERNAL MEDICINE, 2009, 23 (05) : 1064 - 1070
  • [42] Low-dose glucocorticoids suppresses ovarian tumor growth and metastasis in an immunocompetent syngeneic mouse model
    Lin, Kai-Ti
    Sun, Shu-Pin
    Wu, Jui-I
    Wang, Lu-Hai
    PLOS ONE, 2017, 12 (06):
  • [43] Low-Dose IFNγ Induces Tumor Cell Stemness in Tumor Microenvironment of Non-Small Cell Lung Cancer
    Song, Mengjia
    Ping, Yu
    Zhang, Kai
    Yang, Li
    Li, Feng
    Zhang, Chaoqi
    Cheng, Shaoyan
    Yue, Dongli
    Maimela, Nomathamsanqa Resegofetse
    Qu, Jiao
    Liu, Shasha
    Sun, Ting
    Li, Zihai
    Xia, Jianchuan
    Zhang, Bin
    Wang, Liping
    Zhang, Yi
    CANCER RESEARCH, 2019, 79 (14) : 3737 - 3748
  • [44] DNA double-strand break repair and adaptive responses of low-dose radiation in normal and tumor lung cell lines
    Farhadi, Sonia
    Bahreyni-Toossi, Mohammad-Taghi
    Zafari-Ghadim, Navid
    Khademi, Sara
    Sadat-Darbandi, Mahdi
    Azimian, Hosein
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022, 881
  • [45] PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation
    Morisada, Megan
    Clavijo, Paul E.
    Moore, Ellen
    Sun, Lillian
    Chamberlin, Michael
    Van Waes, Carter
    Hodge, James W.
    Mitchell, James B.
    Friedman, Jay
    Allen, Clint T.
    ONCOIMMUNOLOGY, 2018, 7 (03):
  • [46] Low-dose radiation hyper-radiosensitivity in multicellular tumour spheroids
    Guirado, D.
    Aranda, M.
    Ortiz, M.
    Mesa, J. A.
    Zamora, L. I.
    Amaya, E.
    Villalobos, M.
    Lallena, A. M.
    BRITISH JOURNAL OF RADIOLOGY, 2012, 85 (1018) : 1398 - 1406
  • [47] Follow-up consequences of ionizing irradiation low dose effects on the body immune system
    Trakhtenberg, I
    Ivanitskaya, N
    Talakin, Y
    Babitch, T
    FRESENIUS ENVIRONMENTAL BULLETIN, 1996, 5 (3-4): : 121 - 125
  • [48] Low-dose whole-lung irradiation in severe COVID-19 pneumonia: a controlled clinical trial
    Mousavi Darzikolaee, Nima
    Kolahdouzan, Kasra
    Abtahi, Hamidreza
    Kazemizadeh, Hossein
    Salehi, Mohammadreza
    Ghalehtaki, Reza
    Bayani, Reyhaneh
    Pestehei, Seyed Khalil
    Ghazanfari, Tooba
    Ebrahiminasab, Fatemeh
    Salarvand, Samaneh
    Haddad, Peiman
    Kazemian, Ali
    Aghili, Mahdi
    JOURNAL OF MEDICAL RADIATION SCIENCES, 2021, 68 (04) : 396 - 406
  • [49] Systemic antitumor immune response of doped yttria nanoscintillators under low-dose x-ray irradiation
    Sahin, Onur
    Mackeyev, Yuri
    Vijay, Geraldine V.
    Roy, Soumyabrata
    Meiyazhagan, Ashokkumar
    Zahra, Yasmin
    Tezcan, Okan
    Gonzalez, Valeria
    Abousaida, Belal
    Wagner, Holden R.
    Fernandes, Pearl
    Mowzoon-Mogharrabi, Riaz
    Venkatesulu, Bhanu P.
    Hsieh, Cheng-En
    Kim, Joseph B. K.
    Raghuram, Subhiksha
    Zhang, Xiang
    Miller, Kristen A.
    Gao, Guanhui
    Singh, Pankaj K.
    Cho, Sang Hyun
    Papineni, Rao V. L.
    Ajayan, Pulickel M.
    Krishnan, Sunil
    SCIENCE ADVANCES, 2025, 11 (13):
  • [50] The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity
    Weng, Ling
    Williams, Richard O.
    Vieira, Pedro L.
    Screaton, Gavin
    Feldmann, Marc
    Dazzi, Francesco
    ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (08) : 1519 - 1526
12345