Lighting up the tumor fire with low-dose irradiation

被引：31
作者：
Herrera, Fernanda G. [1 ,2 ,3 ]
Romero, Pedro [1 ,3 ]
Coukos, George [1 ,3 ]
机构：
[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, Lausanne, Switzerland
[2] Lausanne Univ Hosp, Dept Oncol, Radiat Oncol Serv, Lausanne, Switzerland
[3] Lausanne Univ Hosp, Dept Oncol, Immunooncol Serv, Lausanne, Switzerland
来源：
TRENDS IN IMMUNOLOGY | 2022年 / 43卷 / 03期
关键词：
CD8(+) T-CELLS; CALRETICULIN EXPOSURE; ANTICANCER CHEMOTHERAPY; RADIOTHERAPY; IMMUNITY; MECHANISMS; RESPONSES; MICROENVIRONMENT; IMMUNOGENICITY; BLOCKADE;
D O I：
10.1016/j.it.2022.01.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Current efforts combining immunotherapy and radiation have focused on high-dose radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; however, these effects are uncommon in patients. Three recent studies in mouse tumor models and human cancer patients show that low-dose radiation (LDRT) delivered to all tumor lesions effectively mobilizes innate and adaptive immunity and synergizes with immunotherapy. These new findings suggest LDRT's potential as an immune amplifier capable of reprogramming the tumor microenvironment, instigating inflammation, and sensitizing 'cold' tumors to immune checkpoint blockade responsiveness.
引用
收藏
页码：173 / 179
页数：7
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