In the striatum, dopamine D-1 receptors are preferentially expressed in striatonigral neurons, and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output to substantia nigra pars reticulata. Such roles of D-1 receptors are important for the control of motor functions. In addition, the roles of D-1 receptors are implicated in reward, cognition, and drug addiction. Therefore, elucidation of mechanisms for the regulation of dopamine D-1 receptor signaling is required to identify therapeutic targets for Parkinson's disease and drug addiction. D-1 receptors are coupled to G(s/olf)/adenylyl cyclase/PKA signaling, leading to the phosphorylation of PKA substrates including DARPP-32. Phosphorylated form of DARPP-32 at Thr34 has been shown to inhibit protein phosphatase-1, and thereby controls the phosphorylation states and activity of many downstream physiological effectors. Roles of DARPP-32 and its phosphorylation at Thr34 and other sites in D-1 receptor signaling are extensively studied. In addition, functional roles of the non-canonical D-1 receptor signaling cascades that coupled to G(q)/phospholipase C or Src family kinase become evident. We have recently shown that phosphodiesterases (PDEs), especially PDE10A, play a pivotal role in regulating the tone of D-1 receptor signaling relatively to that of D-2 receptor signaling. We review the current understanding of molecular mechanisms for the modulation of D-1 receptor signaling in the striatum.
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xing, B.
Kong, H.
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Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R China
Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USAXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Kong, H.
Meng, X.
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Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Meng, X.
Wei, S. G.
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Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Wei, S. G.
Xu, M.
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h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USAXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xu, M.
Li, S. B.
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Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Cepeda, Carlos
Andre, Veronique M.
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Andre, Veronique M.
Yamazaki, Irene
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Yamazaki, Irene
Wu, Nanping
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Wu, Nanping
Kleiman-Weiner, Max
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Kleiman-Weiner, Max
Levine, Michael S.
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
机构:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
Decamp, E
Wade, T
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
Wade, T
Schneider, JS
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h-index: 0
机构:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
机构:
Sophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, JapanSophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, Japan
Yamashita, K
Tanaka, S
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h-index: 0
机构:
Sophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, JapanSophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, Japan
机构:
Umea Univ, Univ Hosp, Dept Radiat Sci, Diagnost Radiol, SE-90187 Umea, Sweden
Umea Univ, Umea Ctr Funct Brain Imaging, SE-90736 Umea, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Axelsson, Jan
Chowdhury, Rumana
论文数: 0引用数: 0
h-index: 0
机构:
Leeds Teaching Hosp Natl Hlth Serv Trust, Dept Neurol, Leeds LS1 3EX, W Yorkshire, EnglandKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Chowdhury, Rumana
Riklund, Katrine
论文数: 0引用数: 0
h-index: 0
机构:
Umea Univ, Univ Hosp, Dept Radiat Sci, Diagnost Radiol, SE-90187 Umea, Sweden
Umea Univ, Umea Ctr Funct Brain Imaging, SE-90736 Umea, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Riklund, Katrine
Dolan, Raymond J.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Max Planck Univ Coll London, Ctr Computat Psychiat & Ageing Res, London WC1B 5EH, EnglandKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Dolan, Raymond J.
Nyberg, Lars
论文数: 0引用数: 0
h-index: 0
机构:
Umea Univ, Univ Hosp, Dept Radiat Sci, Diagnost Radiol, SE-90187 Umea, Sweden
Umea Univ, Umea Ctr Funct Brain Imaging, SE-90736 Umea, Sweden
Umea Univ, Dept Integrat Med Biol, Physiol, SE-90187 Umea, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Nyberg, Lars
Backman, Lars
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Aging Res Ctr, SE-17165 Stockholm, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Backman, Lars
Guitart-Masip, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
UCL, Max Planck Univ Coll London, Ctr Computat Psychiat & Ageing Res, London WC1B 5EH, EnglandKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xing, B.
Kong, H.
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R China
Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USAXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Kong, H.
Meng, X.
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Meng, X.
Wei, S. G.
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h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Wei, S. G.
Xu, M.
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h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USAXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xu, M.
Li, S. B.
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
Xi An Jiao Tong Univ, Minist Forens Sci, Key Lab Hlth, Xian 710061, Shannxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian 710061, Shannxi, Peoples R China
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Cepeda, Carlos
Andre, Veronique M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Andre, Veronique M.
Yamazaki, Irene
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Yamazaki, Irene
Wu, Nanping
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Wu, Nanping
Kleiman-Weiner, Max
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
Kleiman-Weiner, Max
Levine, Michael S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USAUniv Calif Los Angeles, David Geffen Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90053 USA
机构:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
Decamp, E
Wade, T
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
Wade, T
Schneider, JS
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
机构:
Sophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, JapanSophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, Japan
Yamashita, K
Tanaka, S
论文数: 0引用数: 0
h-index: 0
机构:
Sophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, JapanSophia Univ, Lab Cort Circuits & Computat, High Tech Res Ctr, Dept Elect & Elect Engn,Chiyoda Ku, Tokyo 1028554, Japan
机构:
Umea Univ, Univ Hosp, Dept Radiat Sci, Diagnost Radiol, SE-90187 Umea, Sweden
Umea Univ, Umea Ctr Funct Brain Imaging, SE-90736 Umea, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Axelsson, Jan
Chowdhury, Rumana
论文数: 0引用数: 0
h-index: 0
机构:
Leeds Teaching Hosp Natl Hlth Serv Trust, Dept Neurol, Leeds LS1 3EX, W Yorkshire, EnglandKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Chowdhury, Rumana
Riklund, Katrine
论文数: 0引用数: 0
h-index: 0
机构:
Umea Univ, Univ Hosp, Dept Radiat Sci, Diagnost Radiol, SE-90187 Umea, Sweden
Umea Univ, Umea Ctr Funct Brain Imaging, SE-90736 Umea, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Riklund, Katrine
Dolan, Raymond J.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Max Planck Univ Coll London, Ctr Computat Psychiat & Ageing Res, London WC1B 5EH, EnglandKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Dolan, Raymond J.
Nyberg, Lars
论文数: 0引用数: 0
h-index: 0
机构:
Umea Univ, Univ Hosp, Dept Radiat Sci, Diagnost Radiol, SE-90187 Umea, Sweden
Umea Univ, Umea Ctr Funct Brain Imaging, SE-90736 Umea, Sweden
Umea Univ, Dept Integrat Med Biol, Physiol, SE-90187 Umea, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Nyberg, Lars
Backman, Lars
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Aging Res Ctr, SE-17165 Stockholm, SwedenKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
Backman, Lars
Guitart-Masip, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden
UCL, Max Planck Univ Coll London, Ctr Computat Psychiat & Ageing Res, London WC1B 5EH, EnglandKarolinska Inst, Aging Res Ctr, SE-17165 Stockholm, Sweden