Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

被引：17

作者：

Karaaslan, Elif ^{[1
,9
]}

Cetin, Nesibe Selma ^{[1
,2
]}

Kalkan-Yazici, Merve ^{[1
]}

Hasanoglu, Sevde ^{[1
]}

Karakecili, Faruk ^{[3
]}

Ozdarendeli, Aykut ^{[4
,5
,6
]}

Kalkan, Ahmet ^{[7
]}

Kilic, Ali Osman ^{[8
]}

Doymaz, Mehmet Ziya ^{[1
,2
]}

机构：

[1] Bezmialem Vak Univ, Beykoz Inst Life Sci & Biotechnol, Istanbul, Turkey

[2] Bezmialem Vak Univ, Fac Med, Dept Med Microbiol, Istanbul, Turkey

[3] Erzincan Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Erzincan, Turkey

[4] Erciyes Univ, Vectors & Vector Borne Dis Implementat & Res Ctr, Kayseri, Turkey

[5] Erciyes Univ, Dept Microbiol, Sch Med, Kayseri, Turkey

[6] Erciyes Univ, Fac Med, Dept Med Microbiol, Kayseri, Turkey

[7] Karadeniz Tech Univ, Med Fac, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey

[8] Karadeniz Tech Univ, Fac Med, Dept Med Microbiol, Trabzon, Turkey

[9] Ctr Dis Control & Prevent, Special Pathogens Branch, Atlanta, GA USA

来源：

PLOS NEGLECTED TROPICAL DISEASES | 2021年 / 15卷 / 12期

关键词：

INFLUENZA-A VIRUS; VIRAL LOAD; NUCLEOPROTEIN; PROTECTION; REPLICATION; MECHANISMS; EXPRESSION; ANTIBODIES; VACCINES;

D O I：

10.1371/journal.pntd.0009973

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather scarce. Due to its indispensable roles in the viral life cycle, NP becomes a logical target for detailed viral immunology studies. In this study, humoral immunity to NP was investigated in CCHF survivors, as well as in immunized mice and rabbits. Abundant antibody response against NP was demonstrated both during natural infection in humans and following experimental immunizations in mice and rabbits. Also, cellular immune responses to recombinant NP (rNP) was detected in multispecies. This study represents the most comprehensive investigation on NP as an inducer of both humoral and cellular immunity in multiple hosts and proves that rNP is an excellent candidate warranting further immunological studies specifically on vaccine investigations.

引用

页数：20

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