Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence

被引：89

作者：

Lin, Tien-chen ^{[1
]}

Neuner, Annett ^{[1
]}

Schiebel, Elmar ^{[1
]}

机构：

[1] Heidelberg Univ, Zentrum Mol Biol, ZMBH, DKFZ ZMBH Allianz, D-69120 Heidelberg, Germany

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 05期

关键词：

microtubule; gamma-tubulin complex; mitotic spindle; centrosome; spindle pole body; SPINDLE-POLE-BODY; FISSION YEAST; RING COMPLEX; MITOTIC SPINDLE; CG-NAP; SCHIZOSACCHAROMYCES-POMBE; SACCHAROMYCES-CEREVISIAE; CHROMOSOME SEGREGATION; CENTROSOMAL PROTEINS; ASPERGILLUS-NIDULANS;

D O I：

10.1016/j.tcb.2014.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (gamma-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. gamma-TuC recruiting factors not only target the gamma-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing gamma-tubulin ring complexes (gamma-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by gamma-tubulin small complex (gamma-TuSC) receptors. Moreover, we discuss the emergence of gamma-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly.

引用

收藏

页码：296 / 307

页数：12

相关论文

共 127 条

[41] Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins [J].

Hutchins, James R. A. ;

Toyoda, Yusuke ;

Hegemann, Bjoern ;

Poser, Ina ;

Heriche, Jean-Karim ;

Sykora, Martina M. ;

Augsburg, Martina ;

Hudecz, Otto ;

Buschhorn, Bettina A. ;

Bulkescher, Jutta ;

Conrad, Christian ;

Comartin, David ;

Schleiffer, Alexander ;

Sarov, Mihail ;

Pozniakovsky, Andrei ;

Slabicki, Mikolaj Michal ;

Schloissnig, Siegfried ;

Steinmacher, Ines ;

Leuschner, Marit ;

Ssykor, Andrea ;

Lawo, Steffen ;

Pelletier, Laurence ;

Stark, Holger ;

Nasmyth, Kim ;

Ellenberg, Jan ;

Durbin, Richard ;

Buchholz, Frank ;

Mechtler, Karl ;

Hyman, Anthony A. ;

Peters, Jan-Michael .

SCIENCE, 2010, 328 (5978) :593-599

[42] GSK-3β regulates proper mitotic spindle formation in cooperation with a component of the γ-tubulin ring complex, GCP5 [J].

Izumi, Nanae ;

Fumoto, Katsumi ;

Izumi, Shunsuke ;

Kikuchi, Akira .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (19) :12981-12991

[43] Efficient formation of bipolar microtubule bundles requires microtubule-bound γ-tubulin complexes [J].

Janson, ME ;

Setty, TG ;

Paoletti, A ;

Tran, PT .

JOURNAL OF CELL BIOLOGY, 2005, 169 (02) :297-308

[44] Dynamic Recruitment of CDK5RAP2 to Centrosomes Requires Its Association with Dynein [J].

Jia, Yue ;

Fong, Ka-Wing ;

Choi, Yuk-Kwan ;

See, Siu-San ;

Qi, Robert Z. .

PLOS ONE, 2013, 8 (07)

[45] Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1 [J].

Johmura, Yoshikazu ;

Soung, Nak-Kyun ;

Park, Jung-Eun ;

Yu, Li-Rong ;

Zhou, Ming ;

Bang, Jeong K. ;

Kim, Bo-Yeon ;

Veenstra, Timothy D. ;

Erikson, Raymond L. ;

Lee, Kyung S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) :11446-11451

[46] Analysis of a RanGTP-regulated gradient in mitotic somatic cells [J].

Kaláb, P ;

Pralle, A ;

Isacoff, EY ;

Heald, R ;

Weis, K .

NATURE, 2006, 440 (7084) :697-701

[47] Characterization of a Drosophila centrosome protein CP309 that shares homology with kendrin and CG-NAP [J].

Kawaguchi, S ;

Zheng, YX .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (01) :37-45

[48] A Cell Cycle Phosphoproteome of the Yeast Centrosome [J].

Keck, Jamie M. ;

Jones, Michele H. ;

Wong, Catherine C. L. ;

Binkley, Jonathan ;

Chen, Daici ;

Jaspersen, Sue L. ;

Holinger, Eric P. ;

Xu, Tao ;

Niepel, Mario ;

Rout, Michael P. ;

Vogel, Jackie ;

Sidow, Arend ;

Yates, John R., III ;

Winey, Mark .

SCIENCE, 2011, 332 (6037) :1557-1561

[49] PURIFICATION OF A MULTIPROTEIN COMPLEX CONTAINING CENTROSOMAL PROTEINS FROM THE DROSOPHILA EMBRYO BY CHROMATOGRAPHY WITH LOW-AFFINITY POLYCLONAL ANTIBODIES [J].

KELLOGG, DR ;

ALBERTS, BM .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (01) :1-11

[50] Spc110p: Assembly properties and role in the connection of nuclear microtubules to the yeast spindle pole body [J].

Kilmartin, JV ;

Goh, PY .

EMBO JOURNAL, 1996, 15 (17) :4592-4602

← 1 2 3 4 5 6 7 8 9 10 →