Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence

被引：89
作者：
Lin, Tien-chen [1 ]
Neuner, Annett [1 ]
Schiebel, Elmar [1 ]
机构：
[1] Heidelberg Univ, Zentrum Mol Biol, ZMBH, DKFZ ZMBH Allianz, D-69120 Heidelberg, Germany
来源：
TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 05期
关键词：
microtubule; gamma-tubulin complex; mitotic spindle; centrosome; spindle pole body; SPINDLE-POLE-BODY; FISSION YEAST; RING COMPLEX; MITOTIC SPINDLE; CG-NAP; SCHIZOSACCHAROMYCES-POMBE; SACCHAROMYCES-CEREVISIAE; CHROMOSOME SEGREGATION; CENTROSOMAL PROTEINS; ASPERGILLUS-NIDULANS;
D O I：
10.1016/j.tcb.2014.12.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (gamma-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. gamma-TuC recruiting factors not only target the gamma-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing gamma-tubulin ring complexes (gamma-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by gamma-tubulin small complex (gamma-TuSC) receptors. Moreover, we discuss the emergence of gamma-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly.
引用
收藏
页码：296 / 307
页数：12
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