Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

被引：179

作者：

Cao, Qi ^{[1
,2
]}

Mani, Ram-Shankar ^{[1
,2
]}

Ateeq, Bushra ^{[1
,2
]}

Dhanasekaran, Saravana M. ^{[1
,2
]}

Asangani, Irfan A. ^{[1
,2
]}

Prensner, John R. ^{[1
,2
]}

Kim, Jung H. ^{[1
,2
]}

Brenner, J. Chad ^{[1
,2
]}

Jing, Xiaojun ^{[1
,2
]}

Cao, Xuhong ^{[1
,3
]}

Wang, Rui ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Dahiya, Arun ^{[1
]}

Wang, Lei ^{[1
,2
]}

Pandhi, Mithil ^{[1
]}

Lonigro, Robert J. ^{[1
,2
]}

Wu, Yi-Mi ^{[1
,2
]}

Tomlins, Scott A. ^{[1
,2
]}

Palanisamy, Nallasivam ^{[1
,2
,6
]}

Qin, Zhaohui ^{[7
]}

Yu, Jindan ^{[1
,2
]}

Maher, Christopher A. ^{[1
,2
,4
]}

Varambally, Sooryanarayana ^{[1
,2
,6
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,5
,6
]}

机构：

[1] Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[7] Emory Univ, Ctr Comprehens Informat, Dept Biostat & Bioinformat, Atlanta, GA 30329 USA

来源：

CANCER CELL | 2011年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GROUP PROTEIN EZH2; PROSTATE-CANCER; BREAST-CANCER; SELF-RENEWAL; STEM-CELLS; GENE-EXPRESSION; ZESTE HOMOLOG-2; DOWN-REGULATION; GASTRIC-CANCER; E-CADHERIN;

D O I：

10.1016/j.ccr.2011.06.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG) proteins including EZH2, a PRC2 component, are upregulated in various cancer types, implicating their role in tumorigenesis. Here, we have identified several microRNAs (miRNAs) that are repressed by EZH2. These miRNAs, in turn, regulate the expression of PRC1 proteins BMI1 and RING2. We found that ectopic overexpression of EZH2-regulated miRNAs attenuated cancer cell growth and invasiveness, and abrogated cancer stem cell properties. Importantly, expression analysis revealed an inverse correlation between miRNA and PRC protein levels in cell culture and prostate cancer tissues. Taken together, our data have uncovered a coordinate regulation of PRC1 and PRC2 activities that is mediated by miRNAs.

引用

页码：187 / 199

页数：13

共 50 条

[41] Regulation of Mesenchymal Phenotype by MicroRNAs in Cancer
Yan, Jinchun
Gumireddy, Kiranmai
Li, Anping
Huang, Qihong
CURRENT CANCER DRUG TARGETS, 2013, 13 (09) : 930 - 934
[42] Trithorax and Polycomb group-dependent regulation: a tale of opposing activities
Geisler, Sarah J.
Paro, Renato
DEVELOPMENT, 2015, 142 (17): : 2876 - 2887
[43] Regulation of multidrug resistance by microRNAs in anti-cancer therapy
An, Xin
Sarmiento, Cesar
Tan, Tao
Zhu, Hua
ACTA PHARMACEUTICA SINICA B, 2017, 7 (01) : 38 - 51
[44] MicroRNAs in regulation of triple-negative breast cancer progression
Piasecka, Dominika
Braun, Marcin
Kordek, Radzislaw
Sadej, Rafal
Romanska, Hanna
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2018, 144 (08) : 1401 - 1411
[45] The Role of MicroRNAs in the Regulation of Gastric Cancer Stem Cells: A Meta-Analysis of the Current Status
Ruggieri, Vitalba
Russi, Sabino
Zoppoli, Pietro
La Rocca, Francesco
Angrisano, Tiziana
Falco, Geppino
Calice, Giovanni
Laurino, Simona
JOURNAL OF CLINICAL MEDICINE, 2019, 8 (05)
[46] Quercetin-mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer
Farooqi, Ammad Ahmad
Jabeen, Saima
Attar, Rukset
Yaylim, Ilhan
Xu, Baojun
JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (12) : 9664 - 9674
[47] The Influence of microRNAs in Regulation of Hormone Dependence in Prostate Cancer Cells
Tarasov, V. A.
Naboka, A., V
Makhotkin, M. A.
Chikunov, I. E.
Tyutyakina, M. G.
Chebotarev, D. A.
Cherkasova, E. N.
Kogan, M., I
Chibichyan, M. B.
Matishov, D. G.
RUSSIAN JOURNAL OF GENETICS, 2019, 55 (06) : 720 - 727
[48] Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation
Martin, Nadine
Popov, Nikolay
Aguilo, Francesca
O'Loghlen, Ana
Raguz, Selina
Snijders, Ambrosius P.
Dharmalingam, Gopuraja
Li, SiDe
Thymiakou, Efstathia
Carroll, Thomas
Zeisig, Bernd B.
So, Chi Wai Eric
Peters, Gordon
Episkopou, Vasso
Walsh, Martin J.
Gil, Jesus
EMBO JOURNAL, 2013, 32 (07) : 982 - 995
[49] Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
Sauvageau, Martin
Sauvageau, Guy
CELL STEM CELL, 2010, 7 (03) : 299 - 313
[50] The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer
Li, Zhongwu
Wang, Yanling
Qiu, Jing
Li, Qiang
Yuan, Chunping
Zhang, Wei
Wang, Dongmiao
Ye, Jinhai
Jiang, Hongbin
Yang, Jianrong
Cheng, Jie
ONCOTARGET, 2013, 4 (12) : 2532 - 2549

← 1 2 3 4 5 →