Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

被引：179

作者：

Cao, Qi ^{[1
,2
]}

Mani, Ram-Shankar ^{[1
,2
]}

Ateeq, Bushra ^{[1
,2
]}

Dhanasekaran, Saravana M. ^{[1
,2
]}

Asangani, Irfan A. ^{[1
,2
]}

Prensner, John R. ^{[1
,2
]}

Kim, Jung H. ^{[1
,2
]}

Brenner, J. Chad ^{[1
,2
]}

Jing, Xiaojun ^{[1
,2
]}

Cao, Xuhong ^{[1
,3
]}

Wang, Rui ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Dahiya, Arun ^{[1
]}

Wang, Lei ^{[1
,2
]}

Pandhi, Mithil ^{[1
]}

Lonigro, Robert J. ^{[1
,2
]}

Wu, Yi-Mi ^{[1
,2
]}

Tomlins, Scott A. ^{[1
,2
]}

Palanisamy, Nallasivam ^{[1
,2
,6
]}

Qin, Zhaohui ^{[7
]}

Yu, Jindan ^{[1
,2
]}

Maher, Christopher A. ^{[1
,2
,4
]}

Varambally, Sooryanarayana ^{[1
,2
,6
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,5
,6
]}

机构：

[1] Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[7] Emory Univ, Ctr Comprehens Informat, Dept Biostat & Bioinformat, Atlanta, GA 30329 USA

来源：

CANCER CELL | 2011年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GROUP PROTEIN EZH2; PROSTATE-CANCER; BREAST-CANCER; SELF-RENEWAL; STEM-CELLS; GENE-EXPRESSION; ZESTE HOMOLOG-2; DOWN-REGULATION; GASTRIC-CANCER; E-CADHERIN;

D O I：

10.1016/j.ccr.2011.06.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG) proteins including EZH2, a PRC2 component, are upregulated in various cancer types, implicating their role in tumorigenesis. Here, we have identified several microRNAs (miRNAs) that are repressed by EZH2. These miRNAs, in turn, regulate the expression of PRC1 proteins BMI1 and RING2. We found that ectopic overexpression of EZH2-regulated miRNAs attenuated cancer cell growth and invasiveness, and abrogated cancer stem cell properties. Importantly, expression analysis revealed an inverse correlation between miRNA and PRC protein levels in cell culture and prostate cancer tissues. Taken together, our data have uncovered a coordinate regulation of PRC1 and PRC2 activities that is mediated by miRNAs.

引用

页码：187 / 199

页数：13

共 50 条

[21] Regulation of gene expression by modulating microRNAs through Epigallocatechin-3-gallate in cancer
Dharshini, Loganathan Chandramani Priya
Mandal, Abul Kalam Azad
MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)
[22] Curcumin inhibits cancer progression through regulating expression of microRNAs
Zhou, Siying
Zhang, Sijie
Shen, Hongyu
Chen, Wei
Xu, Hanzi
Chen, Xiu
Sun, Dawei
Zhong, Shanliang
Zhao, Jianhua
Tang, Jinhai
TUMOR BIOLOGY, 2017, 39 (02) : 1 - 12
[23] The differential regulation of microRNAs is associated with oral cancer
Tsai, Shih-Chang
Huang, Sheng-Fong
Chiang, Jo-Hua
Chen, Yen-Fu
Huang, Chia-Chang
Tsai, Ming-Hsui
Tsai, Fuu-Jen
Kao, Ming-Ching
Yang, Jai-Sing
ONCOLOGY REPORTS, 2017, 38 (03) : 1613 - 1620
[24] The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?
Scelfo, Andrea
Piunti, Andrea
Pasini, Diego
FEBS JOURNAL, 2015, 282 (09) : 1703 - 1722
[25] Polycomb group proteins: navigators of lineage pathways led astray in cancer
Bracken, Adrian P.
Helin, Kristian
NATURE REVIEWS CANCER, 2009, 9 (11) : 773 - 784
[26] Regulation of cancer metastasis by microRNAs
Shih-Hsuan Chan
Lu-Hai Wang
Journal of Biomedical Science, 22
[27] Regulation of angiogenesis by microRNAs in cancer
Zheng, Qi
Hou, Wei
MOLECULAR MEDICINE REPORTS, 2021, 24 (02)
[28] Polycomb group proteins: New targets of anti-cancer therapy
Kang, Mo K.
CELL CYCLE, 2010, 9 (14) : 2704 - 2704
[29] Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer
Lee, Hyunjoo
Yoon, Sun Och
Jeong, Woon Yong
Kim, Han Kyeom
Kim, Aeree
Kim, Baek-hui
HUMAN PATHOLOGY, 2012, 43 (10) : 1704 - 1710
[30] Coordinated Regulation of Retinoic Acid Signaling Pathway by KDM5B and Polycomb Repressive Complex 2
Zhang, Yu
Liang, Jing
Li, Qian
JOURNAL OF CELLULAR BIOCHEMISTRY, 2014, 115 (09) : 1528 - 1538

← 1 2 3 4 5 →