Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

被引：179

作者：

Cao, Qi ^{[1
,2
]}

Mani, Ram-Shankar ^{[1
,2
]}

Ateeq, Bushra ^{[1
,2
]}

Dhanasekaran, Saravana M. ^{[1
,2
]}

Asangani, Irfan A. ^{[1
,2
]}

Prensner, John R. ^{[1
,2
]}

Kim, Jung H. ^{[1
,2
]}

Brenner, J. Chad ^{[1
,2
]}

Jing, Xiaojun ^{[1
,2
]}

Cao, Xuhong ^{[1
,3
]}

Wang, Rui ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Dahiya, Arun ^{[1
]}

Wang, Lei ^{[1
,2
]}

Pandhi, Mithil ^{[1
]}

Lonigro, Robert J. ^{[1
,2
]}

Wu, Yi-Mi ^{[1
,2
]}

Tomlins, Scott A. ^{[1
,2
]}

Palanisamy, Nallasivam ^{[1
,2
,6
]}

Qin, Zhaohui ^{[7
]}

Yu, Jindan ^{[1
,2
]}

Maher, Christopher A. ^{[1
,2
,4
]}

Varambally, Sooryanarayana ^{[1
,2
,6
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,5
,6
]}

机构：

[1] Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[7] Emory Univ, Ctr Comprehens Informat, Dept Biostat & Bioinformat, Atlanta, GA 30329 USA

来源：

CANCER CELL | 2011年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GROUP PROTEIN EZH2; PROSTATE-CANCER; BREAST-CANCER; SELF-RENEWAL; STEM-CELLS; GENE-EXPRESSION; ZESTE HOMOLOG-2; DOWN-REGULATION; GASTRIC-CANCER; E-CADHERIN;

D O I：

10.1016/j.ccr.2011.06.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG) proteins including EZH2, a PRC2 component, are upregulated in various cancer types, implicating their role in tumorigenesis. Here, we have identified several microRNAs (miRNAs) that are repressed by EZH2. These miRNAs, in turn, regulate the expression of PRC1 proteins BMI1 and RING2. We found that ectopic overexpression of EZH2-regulated miRNAs attenuated cancer cell growth and invasiveness, and abrogated cancer stem cell properties. Importantly, expression analysis revealed an inverse correlation between miRNA and PRC protein levels in cell culture and prostate cancer tissues. Taken together, our data have uncovered a coordinate regulation of PRC1 and PRC2 activities that is mediated by miRNAs.

引用

页码：187 / 199

页数：13

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