Cell-in-Cell Structures in the Liver: A Tale of Four E's

被引：28

作者：

Davies, Scott P. ^{[1
]}

Terry, Lauren V. ^{[1
]}

Wilkinson, Alex L. ^{[1
]}

Stamataki, Zania ^{[1
,2
]}

机构：

[1] Univ Birmingham, Inst Immunol & Immunotherapy, Ctr Liver & Gastrointestinal Res, Birmingham, W Midlands, England

[2] Univ Hosp Birmingham NHS Fdn Trust, NIHR Birmingham Liver Biomed Res Ctr, Birmingham, W Midlands, England

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

基金：

英国惠康基金;

关键词：

cell-in-cell; liver; efferocytosis; entosis; emperipolesis; enclysis; cancer; regeneration; REGULATORY T-CELLS; THYMIC NURSE CELLS; ASIALOGLYCOPROTEIN RECEPTOR; APOPTOTIC CELLS; CLEARANCE; EMPERIPOLESIS; AUTOIMMUNE; ANEUPLOIDY; ENTOSIS; CANNIBALISM;

D O I：

10.3389/fimmu.2020.00650

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The liver is our largest internal organ and it plays major roles in drug detoxification and immunity, where the ingestion of extracellular material through phagocytosis is a critical pathway. Phagocytosis is the deliberate endocytosis of large particles, microbes, dead cells or cell debris and can lead to cell-in-cell structures. Various types of cell endocytosis have been recently described for hepatic epithelia (hepatocytes), which are non-professional phagocytes. Given that up to 80% of the liver comprises hepatocytes, the biological impact of cell-in-cell structures in the liver can have profound effects in liver regeneration, inflammation and cancer. This review brings together the latest reports on four types of endocytosis in the liver -efferocytosis, entosis, emperipolesis and enclysis, with a focus on hepatocyte biology.

引用

页数：10

共 101 条

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