Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids

被引：4

作者：

Adachi, Akimasa ^{[1
]}

Honda, Tetsuya ^{[1
,2
]}

Dainichi, Teruki ^{[1
]}

Egawa, Gyohei ^{[1
]}

Yamamoto, Yosuke ^{[1
]}

Nomura, Takashi ^{[1
]}

Nakajima, Saeko ^{[1
]}

Otsuka, Atsushi ^{[1
]}

Maekawa, Masamitsu ^{[3
]}

Mano, Nariyasu ^{[3
]}

Koyanagi, Naoto ^{[4
,5
]}

Kawaguchi, Yasushi ^{[4
,5
]}

Ohteki, Toshiaki ^{[6
]}

Nagasawa, Takashi ^{[7
,8
]}

Ikuta, Koichi ^{[9
]}

Kitoh, Akihiko ^{[1
]}

Kabashima, Kenji ^{[1
,10
,11
]}

机构：

[1] Kyoto Univ, Dept Dermatol, Grad Sch Med, Kyoto, Japan

[2] Hamamatsu Univ Sch Med, Dept Dermatol, Hamamatsu, Shizuoka, Japan

[3] Tohoku Univ Hosp, Dept Pharmaceut Sci, Sendai, Miyagi, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mol Virol, Tokyo, Japan

[5] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Infect Dis Control, Tokyo, Japan

[6] Tokyo Med & Dent Univ TMDU, Dept Biodef Res, Med Res Inst, Tokyo, Japan

[7] Osaka Univ, Lab Stem Cell Biol & Dev Immunol, Grad Sch Frontier Biosci, Osaka, Japan

[8] Osaka Univ, Grad Sch Med, Osaka, Japan

[9] Osaka Univ, Inst Frontier Life & Med Sci, Dept Virus Res, Lab Immune Regulat, Osaka, Japan

[10] ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore

[11] ASTAR, Skin Res Inst Singapore SRIS, Singapore, Singapore

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2021年 / 148卷 / 06期

基金：

日本学术振兴会;

关键词：

Prolonged high-intensity exercise; HSV-2; glucocorti-coids; corticosterone; CXCR4; CXCL12; plasmacytoid dendritic cell; fluctuation; viral infection; PLASMACYTOID DENDRITIC CELLS; RESPIRATORY-TRACT INFECTIONS; NATURAL-KILLER-CELLS; INFLAMED LYMPH-NODES; BONE-MARROW; MACROPHAGE FUNCTION; PHYSICAL-ACTIVITY; PROTEIN-KINASE; CUTTING EDGE; RECEPTOR;

D O I：

10.1016/j.jaci.2021.04.028

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Epidemiologic studies have yielded conflicting results regarding the influence of a single bout of prolonged high-intensity exercise on viral infection. Objective: We sought to learn whether prolonged high-intensity exercise either exacerbates or ameliorates herpes simplex virus type 2 (HSV-2) infection according to the interval between virus exposure and exercise. Methods: Mice were intravaginally infected with HSV-2 and exposed to run on the treadmill. Results: Prolonged high-intensity exercise 17 hours after infection impaired the clearance of HSV-2, while exercise 8 hours after infection enhanced the clearance of HSV-2. These impaired or enhanced immune responses were related to a transient decrease or increase in the number of blood-circulating plasmacytoid dendritic cells. Exercise-induced glucocorticoids transiently decreased the number of circulating plasmacytoid dendritic cells by facilitating their homing to the bone marrow via the CXCL12-CXCR4 axis, which led to their subsequent increase in the blood. Conclusion: A single bout of prolonged high-intensity exercise can be either deleterious or beneficial to antiviral immunity. (J Allergy Clin Immunol 2021;148:1575-88.)

引用

页码：1575 / +

页数：21

共 73 条

[1] Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny [J].

Ara, T ;

Tokoyoda, K ;

Sugiyama, T ;

Egawa, T ;

Kawabata, K ;

Nagasawa, T .

IMMUNITY, 2003, 19 (02) :257-267

[2] US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice [J].

Asano, S ;

Honda, T ;

Goshima, F ;

Watanabe, D ;

Miyake, Y ;

Sugiura, Y ;

Nishiyama, Y .

JOURNAL OF GENERAL VIROLOGY, 1999, 80 :51-56

[3] Mineralocorticoid receptor signaling reduces numbers of circulating human naive Tcells and increases their CD62L, CCR7, and CXCR4 expression [J].

Besedovsky, Luciana ;

Linz, Barbara ;

Born, Jan ;

Lange, Tanja .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 44 (06) :1759-1769

[4] Role of α1- and β3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse [J].

Bexis, Sotiria ;

Docherty, James R. .

BRITISH JOURNAL OF PHARMACOLOGY, 2009, 158 (01) :259-266

[5] Asthma, allergy and the Olympics: a 12-year survey in elite athletes [J].

Bonini, Matteo ;

Gramiccioni, Claudia ;

Fioretti, Daniela ;

Ruckert, Beate ;

Rinaldi, Monica ;

Akdis, Cezmi ;

Todaro, Antonio ;

Palange, Paolo ;

Carlsen, Kai-Hakon ;

Pelliccia, Antonio ;

Rasi, Guido ;

Bonini, Sergio .

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 15 (02) :184-192

[6] Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan [J].

Campbell, John P. ;

Turner, James E. .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[7] Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance [J].

Casanova-Acebes, Maria ;

Pitaval, Christophe ;

Weiss, Linnea A. ;

Nombela-Arrieta, Cesar ;

Chevre, Raphael ;

A-Gonzalez, Noelia ;

Kunisaki, Yuya ;

Zhang, Dachuan ;

van Rooijen, Nico ;

Silberstein, Leslie E. ;

Weber, Christian ;

Nagasawa, Takashi ;

Frenette, Paul S. ;

Castrillo, Antonio ;

Hidalgo, Andres .

CELL, 2013, 153 (05) :1025-1035

[8] Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen [J].

Caton, Michele L. ;

Smith-Raska, Matthew R. ;

Reizis, Boris .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (07) :1653-1664

[9] Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon [J].

Cella, M ;

Jarrossay, D ;

Facchetti, F ;

Alebardi, O ;

Nakajima, H ;

Lanzavecchia, A ;

Colonna, M .

NATURE MEDICINE, 1999, 5 (08) :919-923

[10] RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity [J].

Chopin, Michael ;

Preston, Simon P. ;

Lun, Aaron T. L. ;

Tellier, Julie ;

Smyth, Gordon K. ;

Pellegrini, Marc ;

Belz, Gabrielle T. ;

Corcoran, Lynn M. ;

Visvader, Jane E. ;

Wu, Li ;

Nutt, Stephen L. .

CELL REPORTS, 2016, 15 (04) :866-878

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