Flavonoid-DNA binding studies and thermodynamic parameters

被引：42

作者：

Janjua, Naveed Kausar ^{[1
]}

Shaheen, Amber ^{[1
]}

Yaqub, Azra ^{[1
]}

Perveen, Fouzia ^{[1
]}

Sabahat, Sana ^{[1
]}

Mumtaz, Misbah ^{[1
]}

Jacob, Claus ^{[2
]}

Ba, Lalla Aicha ^{[2
]}

Mohammed, Hamdoon A. ^{[2
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45230, Pakistan

[2] Univ Saarland, Dept Pharm, D-66123 Saarbrucken, Germany

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2011年 / 79卷 / 05期

关键词：

Flavonoid derivatives; ds.DNA; Spectral binding; Viscometry; Molecular modeling; ANTICANCER DRUG; SPECTROSCOPIC INVESTIGATIONS; FLUORESCENCE PROBE; NEUTRAL RED; COMPLEX; BEHAVIOR;

D O I：

10.1016/j.saa.2011.05.018

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Interactional studies of new flavonoid derivatives (FI) with chicken blood ds.DNA were investigated spectrophotometrically in DMSO-H(2)O (9:1 v/v) at various temperatures. Spectral parameters suggest considerable binding between the flavonoid derivatives studied and ds.DNA. The binding constant values lie in the enhanced-binding range. Thermodynamic parameters obtained from UV Studies also point to strong spontaneous binding of FI with ds.DNA. Viscometric studies complimented the UV results where a small linear increase in relative viscosity of the DNA solution was observed with added optimal flavonoid concentration. An overall mixed mode of interaction (intercalative plus groove binding) is proposed between DNA and flavonoids. Conclusively, investigated flavonoid derivatives are found to be strong DNA binders and seem to be promising drug candidates like their natural analogues. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1600 / 1604

页数：5

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