Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy

被引:21
作者
Oshitari, Toshiyuki [1 ,2 ,3 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Chuo Ku, Inohana 1-8-1, Chiba 2608670, Japan
[2] Int Univ Hlth, Dept Ophthalmol, 4-3 Kozunomori, Narita 2868686, Japan
[3] Welf Sch Med, 4-3 Kozunomori, Narita 2868686, Japan
关键词
neurovascular unit; polyol pathway; oxidative stress; advanced glycation-end product; neuroprotection; vasoprotection; diabetic retinopathy; TRIAMCINOLONE ACETONIDE INJECTION; GLYCATION-END-PRODUCTS; PREVENTS RETINAL NEURODEGENERATION; EXTRACELLULAR-MATRIX COMPONENTS; CALCIUM DOBESILATE PREVENTS; ANTIOXIDANT DEFENSE SYSTEM; MACULAR EDEMA; MULLER CELL; INTRAVITREAL TRIAMCINOLONE; NEURITE REGENERATION;
D O I
10.3390/ijerph19010439
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Diabetic retinopathy has recently been defined as a highly specific neurovascular complication of diabetes. The chronic progression of the impairment of the interdependence of neurovascular units (NVUs) is associated with the pathogenesis of diabetic retinopathy. The NVUs consist of neurons, glial cells, and vascular cells, and the interdependent relationships between these cells are disturbed under diabetic conditions. Clinicians should understand and update the current knowledge of the neurovascular impairments in diabetic retinopathy. Above all, neuronal cell death is an irreversible change, and it is directly related to vision loss in patients with diabetic retinopathy. Thus, neuroprotective and vasoprotective therapies for diabetic retinopathy must be established. Understanding the physiological and pathological interdependence of the NVUs is helpful in establishing neuroprotective and vasoprotective therapies for diabetic retinopathy. This review focuses on the pathogenesis of the neurovascular impairments and introduces possible neurovascular protective therapies for diabetic retinopathy.
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页数:19
相关论文
共 155 条
[1]   The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration [J].
Altmann, Christine ;
Schmidt, Mirko H. H. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (01)
[2]  
[Anonymous], 1991, OPHTHALMOLOGY, V98, P786
[3]   Current understanding of the molecular and cellular pathology of diabetic retinopathy [J].
Antonetti, David A. ;
Silva, Paolo S. ;
Stitt, Alan W. .
NATURE REVIEWS ENDOCRINOLOGY, 2021, 17 (04) :195-206
[4]   Mechanisms of Disease Diabetic Retinopathy [J].
Antonetti, David A. ;
Klein, Ronald ;
Gardner, Thomas W. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (13) :1227-1239
[5]   Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice [J].
Arroba, Ana I. ;
Alcalde-Estevez, Elena ;
Garcia-Ramirez, Marta ;
Cazzoni, Daniele ;
de la Villa, Pedro ;
Sanchez-Fernandez, Elena M. ;
Ortiz Mellet, Carmen ;
Garcia Fernandez, Jose M. ;
Hernandez, Cristina ;
Simo, Rafael ;
Valverde, Angela M. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2016, 1862 (09) :1663-1674
[6]   S100B Protein Stimulates Microglia Migration via RAGE-dependent Up-regulation of Chemokine Expression and Release [J].
Bianchi, Roberta ;
Kastrisianaki, Eirini ;
Giambanco, Ileana ;
Donato, Rosario .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (09) :7214-7226
[7]  
Bikbova G, 2017, CURR DIABETES REV, V13, P280, DOI 10.2174/1573399812666160519111333
[8]   Combination of Neuroprotective and Regenerative Agents for AGE-Induced Retinal Degeneration: In Vitro Study [J].
Bikbova, Guzel ;
Oshitari, Toshiyuki ;
Baba, Takayuki ;
Yamamoto, Shuichi .
BIOMED RESEARCH INTERNATIONAL, 2017, 2017
[9]   Altered Expression of NF-κB and SP1 after Exposure to Advanced Glycation End-Products and Effects of Neurotrophic Factors in AGEs Exposed Rat Retinas [J].
Bikbova, Guzel ;
Oshitari, Toshiyuki ;
Baba, Takayuki ;
Yamamoto, Shuichi .
JOURNAL OF DIABETES RESEARCH, 2015, 2015
[10]   Neurite regeneration in adult rat retinas exposed to advanced glycation end-products and regenerative effects of neurotrophin-4 [J].
Bikbova, Guzel ;
Oshitari, Toshiyuki ;
Yamamoto, Shuichi .
BRAIN RESEARCH, 2013, 1534 :33-45