Tissue engineered scaffolds for corneal endothelial regeneration: a material's perspective

被引:13
作者
Delaey, Jasper [1 ]
De Vos, Lobke [1 ]
Koppen, Carina [2 ,3 ]
Dubruel, Peter [1 ]
Van Vlierberghe, Sandra [1 ]
Van den Bogerd, Bert [2 ]
机构
[1] Univ Ghent, Ctr Macromol Chem CMaC, Dept Organ & Macromol Chem, Polymer Chem & Biomat Grp, Ghent, Belgium
[2] Univ Antwerp, Fac Med, Translat Neurosci, Antwerp Res Grp Ocular Sci ARGOS, Antwerp, Belgium
[3] Antwerp Univ Hosp, Dept Ophthalmol, Edegem, Belgium
关键词
DESCEMETS-MEMBRANE; MECHANICAL-PROPERTIES; COLLAGEN VITRIGEL; HYDROGEL FILMS; SERUM-ALBUMIN; CELL SHEET; PERMEABILITY; TRANSPLANTATION; TRANSPORT; PROLIFERATION;
D O I
10.1039/d1bm02023d
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Currently, the treatment of corneal diseases caused by damage to the corneal endothelium requires a donor cornea. Because of their limited availability (1 donor cornea for 70 patients in need), researchers are investigating alternative approaches that are independent of donor tissue. One of them includes the development of a tissue engineered scaffold onto which corneal endothelial cells are seeded. In order to function as a suitable substrate, some of its essential properties including thickness, permeability, transparency and mechanical strength should meet certain demands. Additionally, the membrane should be biocompatible and allow the formation of a functional endothelium on the surface. Many materials have already been investigated in this regard including natural, semi-synthetic and synthetic polymers. In the current review, we present an overview of their characteristics and provide a critical view on the methods exploited for material characterization. Next, also the suitability of scaffolds to serve their purpose is discussed along with an overview of natural tissues (e.g. amniotic membrane and lens capsule) previously investigated for this application. Eventually, we propose a consistent approach to be exploited ideally for membrane characterization in future research. This will allow a scientifically sound comparison of materials and membranes investigated by different research groups, hence benefitting research towards the creation of a suitable/optimal tissue engineered endothelial graft.
引用
收藏
页码:2440 / 2461
页数:22
相关论文
共 113 条
  • [1] Nanoscale topography of the corneal epithelial basement membrane and Descemet's membrane of the human
    Abrams, GA
    Schaus, SS
    Goodman, SL
    Nealey, PF
    Murphy, CJ
    [J]. CORNEA, 2000, 19 (01) : 57 - 64
  • [2] Use of electrospinning technique for biomedical applications
    Agarwal, Seema
    Wendorff, Joachim H.
    Greiner, Andreas
    [J]. POLYMER, 2008, 49 (26) : 5603 - 5621
  • [3] Formation of hydrated layers in PMMA thin films in aqueous solution
    Akers, Peter W.
    Nelson, Andrew R. J.
    Williams, David E.
    McGillivray, Duncan J.
    [J]. APPLIED SURFACE SCIENCE, 2015, 353 : 829 - 834
  • [4] [Anonymous], 2011, BIODEGRADABLE POLYM
  • [5] Arras, 2021, FRONT MED, V8, P1
  • [6] Biomechanical properties of the lens capsule: A review
    Avetisov, K. S.
    Bakhchieva, N. A.
    Avetisov, S. E.
    Novikov, I. A.
    Frolova, A. A.
    Akovantseva, A. A.
    Efremov, Yu M.
    Kotova, S. L.
    Timashev, P. S.
    [J]. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2020, 103
  • [7] Comparison of posterior lamellar keratoplasty techniques to penetrating keratoplasty
    Bahar, Irit
    Kaiserman, Igor
    McAllum, Penny
    Slomovic, Allan
    Rootman, David
    [J]. OPHTHALMOLOGY, 2008, 115 (09) : 1525 - 1533
  • [8] The Young's modulus of fetal preterm and term amniotic membranes
    Benson-Martin, Janine
    Zammaretti, Prisca
    Bilic, Grozdana
    Schweizer, Thomas
    Portmann-Lanz, Bettina
    Burkhardt, Tilo
    Zimmermann, Roland
    Ochsenbein-Koelble, Nicole
    [J]. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2006, 128 (1-2): : 103 - 107
  • [9] Quarter-Descemet Membrane Endothelial Keratoplasty: One- to Two-Year Clinical Outcomes
    Birbal, Renuka S.
    Dhubhghaill, Sorcha Ni
    Baydoun, Lamis
    Ham, Lisanne
    Bourgonje, Vincent J. A.
    Dapena, Isabel
    Oellerich, Silke
    Melles, Gerrit R. J.
    [J]. CORNEA, 2020, 39 (03) : 277 - 282
  • [10] BOETTNER EA, 1962, INVEST OPHTH VISUAL, V1, P776