Epigenetics in the Diagnosis and Therapy of Malignant Melanoma

被引：11

作者：

Santourlidis, Simeon ^{[1
]}

Schulz, Wolfgang A. ^{[2
]}

Arauzo-Bravo, Marcos J. ^{[3
,4
]}

Gerovska, Daniela ^{[3
]}

Ott, Pauline ^{[1
]}

Bendhack, Marcelo L. ^{[5
]}

Hassan, Mohamed ^{[6
,7
]}

Erichsen, Lars ^{[8
]}

机构：

[1] Heinrich Heine Univ Duesseldorf, Epigenet Core Lab, Inst Transplantat Diagnost & Cell Therapeut, Med Fac, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ Duesseldorf, Med Fac, Dept Urol, D-40225 Dusseldorf, Germany

[3] Biodonostia Hlth Res Inst, Grp Computat Biol & Syst Biomed, San Sebastian 20014, Spain

[4] Basque Fdn Sci, Ikerbasque, Bilbao 48009, Spain

[5] Positivo Univ, Univ Hosp, Dept Urol, BR-80030200 Curitiba, Parana, Brazil

[6] Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

[7] Univ Strasbourg, Inst Natl Sante & Rech Med, F-67000 Strasbourg, France

[8] Heinrich Heine Univ Dusseldorf, Med Fac, Inst Stem Cell Res & Regenerat Med, D-40225 Dusseldorf, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

melanoma; DNA methylation; epigenetics; GENOME-WIDE ANALYSIS; DNA-METHYLATION; CUTANEOUS MELANOMA; CHROMATIN ACCESSIBILITY; EXPRESSION; PROTEINS; PROMOTER; CAS9; RNA; METHYLTRANSFERASE;

D O I：

10.3390/ijms23031531

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetic mechanisms are fundamentally important for cancer initiation and development. However, a survey of the literature reveals that, to date, they appear less comprehensively investigated in melanoma than in many other cancers, e.g., prostate, breast, and colon carcinoma. The aim of this review is to provide a short summary of epigenetic aspects of functional relevance for melanoma pathogenesis. In addition, some new perspectives from epigenetic research in other cancers with potential for melanoma diagnosis and therapy are introduced. For example, the PrimeEpiHit hypothesis in urothelial carcinoma, which, similarly to malignant melanoma, can also be triggered by a single exogenous noxa, states that one of the first steps for cancer initiation could be epigenetic changes in key genes of one-carbon metabolism. The application of such insights may contribute to further progress in the diagnosis and therapy of melanoma, a deadly type of cancer.

引用

页数：13

共 73 条

[11] BRAF/NRAS Mutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma [J].