Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core-shell structure

被引：906

作者：

Zhu, YF ^{[1
]}

Shi, JL ^{[1
]}

Shen, WH ^{[1
]}

Dong, XP ^{[1
]}

Feng, JW ^{[1
]}

Ruan, ML ^{[1
]}

Li, YS ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 32期

关键词：

drug delivery; mesoporous materials; multilayers; nanostructures; polyelectrolytes;

D O I：

10.1002/anie.200501500

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Keeping drugs under control: Hydrothermally stable, hollow mesoporous silica spheres have a high drug storage capacity, and polyelectrolyte multilayers coated on the spheres act as a switch for drug release which is controlled by the pH or ionic strength of the release medium. The picture shows the release of ibuprofen (IBU) from spheres with and without coatings of sodium polystyrene sulfonate (PSS) and poly(allylamine hydrochloride) (PAH). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5083 / 5087

页数：5

共 33 条

[1] Nano-encapsulation of furosemide microcrystals for controlled drug release [J].