Vascular endothelial growth factor and thymidine phosphorylase expression in salivary gland tumors with distinct metastatic behavior

被引：13

作者：

de Faria, Paulo Rogerio ^{[2
]}

Lima, Roberto Araujo ^{[3
]}

Dias, Fernando Luiz ^{[3
]}

Silvestre de Faria, Paulo Antonio ^{[4
]}

Amaral Eisenberg, Ana Lucia ^{[4
]}

do Nascimento Souza, Kelen Christine ^{[1
,5
]}

Cardoso, Sergio Vitorino ^{[1
]}

Loyola, Adriano Mota ^{[1
]}

机构：

[1] Univ Fed Uberlandia, Lab Oral & Maxillofacial Pathol, Sch Dent, BR-38405900 Uberlandia, MG, Brazil

[2] Univ Fed Uberlandia, Inst Biomed Sci, BR-38405900 Uberlandia, MG, Brazil

[3] Brazilian Natl Canc Inst, Sect Head & Neck Surg, Rio De Janeiro, Brazil

[4] Brazilian Natl Canc Inst, Div Pathol, Rio De Janeiro, Brazil

[5] Univ Fed Triangulo Mineiro, Dept Pathol, Uberlandia, MG, Brazil

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2011年 / 40卷 / 06期

关键词：

angiogenesis; prognosis; salivary gland tumors; thymidine phosphorylase; vascular endothelial growth factor; ANGIOGENESIS; CARCINOMA; P53;

D O I：

10.1111/j.1600-0714.2010.00980.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

BACKGROUND: Metastasis of salivary gland tumors has a negative impact on survival. Angiogenesis and its factors are potential markers for predicting metastasis in different malignant tumors, but this is not the case for salivary gland tumors. METHODS: Salivary gland tumors of distinct biologic behavior were analyzed according to the semiquantitative immunoexpression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP). RESULTS: Vascular endothelial growth factor expression was predominantly weak in benign tumors. Weak TP expression was observed in 100% cases of benign tumors and in 74.3% of primary malignant tumors. High VEGF and TP expression levels were significantly associated with primary malignant tumors but not with primary non-metastasizing and primary metastasizing malignant tumors or with subtypes of malignant tumors. CONCLUSIONS: Vascular endothelial growth factor and TP expression levels discriminate benign and malignant tumors but cannot predict metastasis from non-metastasizing tumors. J Oral Pathol Med (2011) 40: 456-459

引用

页码：456 / 459

页数：4

共 13 条

[11] Correlation between tumor angiogenesis and expression of thymidine phosphorylase, and patient outcome in uterine cervical carcinoma [J].

Ueda, M ;

Terai, Y ;

Kumagai, K ;

Ueki, K ;

Okamoto, Y ;

Ueki, M .

HUMAN PATHOLOGY, 1999, 30 (11) :1389-1394

[12]

Yu Feng, 2003, Shanghai Kou Qiang Yi Xue, V12, P443

[13] In vitro angiogenesis and expression of nuclear factor κB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma [J].

Zhang, Jiali ;

Peng, Bin .

BMC CANCER, 2007, 7 (1)

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