Vascular endothelial growth factor and thymidine phosphorylase expression in salivary gland tumors with distinct metastatic behavior

被引：13

作者：

de Faria, Paulo Rogerio ^{[2
]}

Lima, Roberto Araujo ^{[3
]}

Dias, Fernando Luiz ^{[3
]}

Silvestre de Faria, Paulo Antonio ^{[4
]}

Amaral Eisenberg, Ana Lucia ^{[4
]}

do Nascimento Souza, Kelen Christine ^{[1
,5
]}

Cardoso, Sergio Vitorino ^{[1
]}

Loyola, Adriano Mota ^{[1
]}

机构：

[1] Univ Fed Uberlandia, Lab Oral & Maxillofacial Pathol, Sch Dent, BR-38405900 Uberlandia, MG, Brazil

[2] Univ Fed Uberlandia, Inst Biomed Sci, BR-38405900 Uberlandia, MG, Brazil

[3] Brazilian Natl Canc Inst, Sect Head & Neck Surg, Rio De Janeiro, Brazil

[4] Brazilian Natl Canc Inst, Div Pathol, Rio De Janeiro, Brazil

[5] Univ Fed Triangulo Mineiro, Dept Pathol, Uberlandia, MG, Brazil

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2011年 / 40卷 / 06期

关键词：

angiogenesis; prognosis; salivary gland tumors; thymidine phosphorylase; vascular endothelial growth factor; ANGIOGENESIS; CARCINOMA; P53;

D O I：

10.1111/j.1600-0714.2010.00980.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

BACKGROUND: Metastasis of salivary gland tumors has a negative impact on survival. Angiogenesis and its factors are potential markers for predicting metastasis in different malignant tumors, but this is not the case for salivary gland tumors. METHODS: Salivary gland tumors of distinct biologic behavior were analyzed according to the semiquantitative immunoexpression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP). RESULTS: Vascular endothelial growth factor expression was predominantly weak in benign tumors. Weak TP expression was observed in 100% cases of benign tumors and in 74.3% of primary malignant tumors. High VEGF and TP expression levels were significantly associated with primary malignant tumors but not with primary non-metastasizing and primary metastasizing malignant tumors or with subtypes of malignant tumors. CONCLUSIONS: Vascular endothelial growth factor and TP expression levels discriminate benign and malignant tumors but cannot predict metastasis from non-metastasizing tumors. J Oral Pathol Med (2011) 40: 456-459

引用

页码：456 / 459

页数：4

共 13 条

[1]

[Anonymous], 2005, World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours

[2]

Doi R, 1999, J ORAL PATHOL MED, V28, P259

[3] Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas [J].

Du, JR ;

Jiang, Y ;

Zhang, YM ;

Fu, H .

WORLD JOURNAL OF GASTROENTEROLOGY, 2003, 9 (07) :1604-1606

[4] PLATELET-DERIVED ENDOTHELIAL-CELL GROWTH-FACTOR THYMIDINE PHOSPHORYLASE EXPRESSION IN NORMAL-TISSUES - AN IMMUNOHISTOCHEMICAL STUDY [J].

FOX, SB ;

MOGHADDAM, A ;

WESTWOOD, M ;

TURLEY, H ;

BICKNELL, R ;

GATTER, KC ;

HARRIS, AL .

JOURNAL OF PATHOLOGY, 1995, 176 (02) :183-190

[5]

Lequerica-Fernández P, 2007, ANTICANCER RES, V27, P3661

[6] Expression of vascular endothelial growth factor in salivary gland carcinomas and its relation to p53, Ki-67 and prognosis [J].

Lim, JJ ;

Kang, SM ;

Lee, MR ;

Pai, HK ;

Yoon, HJ ;

Lee, JI ;

Hong, SP ;

Lim, CY .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2003, 32 (09) :552-561

[7]

Maeda K, 1996, CANCER, V77, P858, DOI 10.1002/(SICI)1097-0142(19960301)77:5<858::AID-CNCR8>3.0.CO

[8]

2-A

[9] Expression of thymidylate synthase and thymidine phosphorylase in human breast carcinoma: implication for method to detect expression of these molecules in clinic [J].

Ogura, O ;

Kanzaki, A ;

Bando, H ;

Ogura, T ;

Toi, M ;

Takebayashi, Y .

CANCER LETTERS, 2003, 190 (01) :97-104

[10]

Tsujitani S, 2004, ANTICANCER RES, V24, P1853

← 1 2 →