Asymmetric synthesis of functionalized 1,2,3,4-tetrahydroquinolines

被引：36

作者：

Gallou-Dagommer, I ^{[1
]}

Gastaud, P ^{[1
]}

RajanBabu, TV ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 13期

关键词：

D O I：

10.1021/ol016018b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Highly enantioselective rhodium-catalyzed asymmetric hydrogenation (> 98% ee) and Sharpless epoxidation (> 90% ee) of o-nitrocinnamyl substrates lead to intermediates that can be transformed into tetrahydroquinoline derivatives, Starting materials are produced in high-yielding Heck reactions of an o-nitroaryl iodide and alpha -acetamidoacrylate or methyl acrylate.

引用

页码：2053 / 2056

页数：4

共 49 条

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