Total Synthesis of Pederin and Analogues

被引：24

作者：

Wu, Fanghui ^{[1
]}

Green, Michael E. ^{[1
]}

Floreancig, Paul E. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 05期

基金：

美国国家科学基金会;

关键词：

cyanides; multicomponent reactions; natural products; oxygen heterocycles; total synthesis; UNCULTIVATED BACTERIAL SYMBIONTS; ALDOL ADDITION-REACTIONS; MYCALAMIDE-B; STEREOSELECTIVE-SYNTHESIS; 1,5-ASYMMETRIC INDUCTION; EFFICIENT SYNTHESIS; ANTITUMOR AGENTS; METHYL KETONES; THEOPEDERIN-D; RIGHT HALF;

D O I：

10.1002/anie.201006438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A ten-step program: The potent cytotoxin pederin and several analogues have been prepared through an efficient route that proceeds in ten steps (longest linear sequence) from isobutyraldehyde. The key transformation is a multicomponent N-acylaminal construction (see scheme) that allows for late-stage fragment coupling and diversification. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1131 / 1134

页数：4

共 43 条

[1]

Cardani C., 1965, TETRAHEDRON LETT, V6, P2537, DOI 10.1016/S0040-4039(01)84020-X

[2] ANTIBIOTICS AND COMPOUNDS AFFECTING TRANSLATION BY EUKARYOTIC RIBOSOMES - SPECIFIC ENHANCEMENT OF AMINOACYL-TRANSFER-RNA BINDING BY METHYLXANTHINES [J].