Copper-Catalyzed Enantioselective Propargylic Etherification of Propargylic Esters with Alcohols

被引：156

作者：

Nakajima, Kazunari ^{[1
]}

Shibata, Masashi ^{[1
]}

Nishibayashi, Yoshiaki ^{[1
]}

机构：

[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 07期

基金：

日本学术振兴会;

关键词：

SUBSTITUTION-REACTIONS; BETA-KETOESTERS; CLICK CHEMISTRY; COMPLEXES; ALKYLATION; AMINATION; ACETATES; AMINES; CYCLOADDITION; ENAMINES;

D O I：

10.1021/jacs.5b00004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective propargylic etherification of propargylic esters with not only aliphatic alcohols but also phenols in the presence of a catalytic amount of copper-Pybox complex gives the corresponding propargylic ethers in good to high yields with a high to excellent enantioselectivity (up to 99% ee). The result described here provides the first successful example of enantioselective propargylic etherification

引用

页码：2472 / 2475

页数：4

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