Infection control issues in patients with haematological malignancies in the era of multidrug-resistant bacteria

被引:76
作者
Ruhnke, Markus [1 ]
Arnold, Renate [2 ]
Gastmeier, Petra [3 ]
机构
[1] Paracelsus Hosp Osnabruck, Dept Hematol & Oncol, D-49076 Osnabruck, Germany
[2] Charite Campus Virchow Klinikum, Dept Med, Div Haematol Oncol & Tumour Immunol, Berlin, Germany
[3] Charite Campus Benjamin Franklin, Dept Med, Div Haematol Oncol & Tumour Immunol, Berlin, Germany
关键词
BLOOD-STREAM INFECTIONS; ANTIMICROBIAL STEWARDSHIP PROGRAM; FEBRILE NEUTROPENIC PATIENTS; LACTAMASE-PRODUCING ENTEROBACTERIACEAE; BONE-MARROW-TRANSPLANTATION; ENTEROCOCCUS VRE BACTEREMIA; 4TH EUROPEAN CONFERENCE; GRAM-NEGATIVE BACILLI; RETAIL CHICKEN MEAT; STAPHYLOCOCCUS-AUREUS;
D O I
10.1016/S1470-2045(14)70344-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Drug-resistant Gram-negative and Gram-positive bacteria are now increasingly identified as a cause of infections in immunocompromised hosts. Bacteria identified include the multidrug-resistant (MDR) and even pandrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa, as well as carbapenem-resistant Enterobacteriaceae spp. The threat from MDR pathogens has been well-documented in the past decade with warnings about the consequences of inappropriate use of antimicrobial drugs. Resistant bacteria can substantially complicate the treatment of infections in critically ill patients and can have a substantial effect on mortality. Inappropriate antimicrobial treatment can affect morbidity, mortality, and overall health-care costs. Evidence-based data for prevention and control of MDR pathogen infections in haematology are scarce. Although not yet established a bundle of infection control and prevention measures with an anti-infective stewardship programme is an important strategy in infection control, diagnosis, and antibiotic selection with optimum regimens to ensure a successful outcome for patients.
引用
收藏
页码:E606 / E619
页数:14
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